Skip to main content
Book cover

Lasers, Lights and Other Technologies pp 487–502Cite as

Microneedling for Transepidermal Drug Delivery on Stretch Marks

  • 1936 Accesses

Part of the Clinical Approaches and Procedures in Cosmetic Dermatology book series (CAPCD)

Abstract

Stretch marks (SMs) are a well-recognized, common skin condition that rarely cause any significant medical problems but are often a significant source of distress to those affected. The origins of SM are poorly understood, and a number of treatment modalities (Elsaie et al. 2009) are available for their treatment, yet none of them is consistently effective, and no single therapy is considered to be consensus for this problem. Multiple sittings of treatments such as chemical peelings, microdermabrasion, nonablative and ablative laser techniques, and light and radiofrequency devices are performed to improve the SM appearance. Microneedling and transepidermal drug delivery together are a new modality of treatment for SM. It is based on stimulation of collagen production and enhancement of the penetration of certain active substances across the skin with which it is possible to achieve satisfactory results.

Keywords

  • Microneedling
  • Transdermal drug delivery
  • Transepidermal drug delivery
  • Stretch marks
  • Collagen

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

References

  • Al-Himdani S, Ud-Din S, Gilmore S, Bayat A. Striae distensae: a comprehensive review and evidence-based evaluation of prophylaxis and treatment. British J Dermatol. 2014;170:527–47.

    CAS  CrossRef  Google Scholar 

  • Alster TS, Handrick C. Laser treatment of hypertrophic scars, keloids and striae. Semin Cutan Med Surg. 2000;19:287–92.

    CAS  CrossRef  PubMed  Google Scholar 

  • Alster TS, Handrick C. Laser treatment of scars and striae. In: Kuvar ANB, Hruza G, editors. Principles and practice.es in cutaneous laser surgery. New York: Marcel Decker; 2005. p. 625–41.

    Google Scholar 

  • Aust MC, Knobloch K, Reimers K, Redeker J, Ipaktchi R, Altintas ML, Gohritz A, Schwaiger N, Vogt PM. Percutaneous collagen induction therapy: an alternative treatment for burn scars. Burns. 2010;36(6):836–43.

    Google Scholar 

  • Aust M, et al. Percutaneous collagen induction therapy: an alternative treatment for scars, wrinkles, and skin laxity. Plast Reconst Surg. 2008;121(4):1421–9.

    CAS  CrossRef  PubMed  Google Scholar 

  • Berlin AL, Mussarratt H, Goldbergv DJ. Calcium hydroxylapatite filler for facial rejuvenation: a histologic and immunohistochemical analysis. Dermatol Surg. 2008;34:S64–7.

    Google Scholar 

  • Bernard FX. Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epi- dermis and normal human skin: transcriptional effects of retinoid treatments in reconstituted human epidermis. Exp Dermatol. 2002;11:59.

    CAS  CrossRef  PubMed  Google Scholar 

  • Brauer J, et al. Convergence of anatomy, technology, and therapeutics: a review of laser-assisted drug delivery. Semin Cutan Med Surg. 2014;33:176.

    CrossRef  PubMed  Google Scholar 

  • Budamakuntla L. A randomised, open-label, comparative study of tranexamic acid microinjections and tranexamic acid with microneedling in patients with melasma. J Cutan Aesthet Surg. 2013;6(3):139.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Camirand A, Doucet J. Needle dermabrasion. Aesthet Plast Surg. 1997;21:48–51.

    CAS  CrossRef  Google Scholar 

  • Casabona G, Michalany N. Ultrasound with visualization and fillers for increased neocollagenesis: clinical and histological evaluation. Dermatol Surg. 2014;40:S194–8.

    Google Scholar 

  • Chawla S. Split face comparative study of microneedling with PRP versus microneedling with vitamin C in treating atrophic post acne scars. J Cutan Aesthet Surg. 2014;7(4):209–12.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Cho CW. In vitro characterization of the invasiveness of polymer microneedle against skin. Int J Pharm. 2010;397:201–5.

    CrossRef  PubMed  Google Scholar 

  • Elsaie ML MD, Baumann LS MD, Elsaaiee LT MD. Striae distensae (Stretch Marks) and different modalities of therapy: an update. Dermatol Surg. 2009;35:563–73.

    CAS  CrossRef  PubMed  Google Scholar 

  • Falabella AF, Falanga V. Wound healing. In: Feinkel RK, Woodley DT, editors. The biology of the skin. New York: Parthenon; 2000. p. 281–99.

    Google Scholar 

  • Faler BJ. Transforming growth factor-beta and wound healing. Perspect Vasc Surg Endovasc Ther. 2006;18:55.

    CrossRef  PubMed  Google Scholar 

  • Fat graft.

    Google Scholar 

  • Fenske NA. Structural and functional changes of normal aging skin. J Am Acad Dermatol. 1986;15:571.

    CAS  CrossRef  PubMed  Google Scholar 

  • Fernandes D. Percutaneous collagen induction: an alternative to laser resurfacing. Aesthetic Surg J. 2002;22:315.

    CrossRef  Google Scholar 

  • Fernandes D. Minimally invasive percutaneous collagen induction. Oral Maxillofac Surg Clin North Am. 2006;17:51–63.

    CrossRef  Google Scholar 

  • Fisher C. Retinoid receptors and keratinocytes. Crit Rev Oral Biol Med. 1995;6:284.

    CAS  CrossRef  PubMed  Google Scholar 

  • Gold MH MD. Noninvasive skin tightening treatment. J Clin Aesthet Dermatol. 2015;8(6):14–8.

    PubMed  PubMed Central  Google Scholar 

  • Goldberg DJ, Marmur ES, Schmults C, Hussain M, Phelps R. Histologic and ultrastructural analysis of ultraviolet B laser and light source treatment of leukoderma in striae distensae. Dermatol Surg. 2005;31:385–7.

    CAS  CrossRef  PubMed  Google Scholar 

  • Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci. 1998;87:922–5. 33) Noh Y-W, Kim T-H, Baek J-S, Park H-H, Lee SS, Han M, Shin SC.

    CAS  CrossRef  PubMed  Google Scholar 

  • Ibrahim ZA1, El-Tatawy RA1, El-Samongy MA1, Ali DA2. Comparison between the efficacy and safety of platelet-rich plasma vs. microdermabrasion in the treatment of striae distensae: clinical and histopathological study. J Cosmet Dermatol. 2015;14:336.

    CrossRef  PubMed  Google Scholar 

  • Johnstone CC. The physiological basics of wound healing. Nurs Stand. 2005;19:59.

    CrossRef  PubMed  Google Scholar 

  • Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, et al. Lack of pain associated with microfabricated microneedles. Anesth Analg. 2001;92:502–4.

    CAS  CrossRef  PubMed  Google Scholar 

  • Kumar V, Banga AK. Modulated iontophoretic delivery of small and large molecules through microchannels. Int J Pharm. 2012;434:106–14.

    CAS  CrossRef  PubMed  Google Scholar 

  • Lima E, Lima M, Takano D. Microneedling experimental study and classification of the resulting injury. Surg Cosmet Dermatol. 2013;5(2):110–4.

    Google Scholar 

  • Lynch SE. Growth factors in wound healing: single and synergistic effects on partial thickness porcine skin wounds. J Clin Invest. 1989;84:640.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Majid I. Microneedling therapy in atrophic facial scars: an objective assessment. J Cutan Aesthet Surg. 2009;2:26–30.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Martin P. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15:599.

    CAS  CrossRef  PubMed  Google Scholar 

  • McCrudden MTC, McAlister E, Courtenay AJ, Gonzalez-Vazquez P, Raghu T, Singh R, Donnelly RF. Microneedle applications in improving skin appearance. Exp Dermatol. 2015;24:561–6.

    CrossRef  PubMed  Google Scholar 

  • McDaniel D. Laser therapy of stretch marks. Dermatol Clinics. 2002;20(1):67–76.

    CrossRef  Google Scholar 

  • Menon GK, Cleary GW, Lane ME. The structure and function of the stratum corneum. Int J Pharm. 2012;435:3–9.

    CAS  CrossRef  PubMed  Google Scholar 

  • Milewski M, Brogden NK, Stinchcomb AL. Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin. Expert Opin Drug Deliv. 2010;7:617–29.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Nusgens BV. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol. 2001;116:853.

    CAS  CrossRef  PubMed  Google Scholar 

  • Oh JH, Kim W, Park KU, Roh YH. Comparison of the cellular composition and cytokine-release kinetics of various platelet-rich plasma preparations. Am J Sports Med. 2015;43:3062.

    Google Scholar 

  • Oliveira MB, Prado AHd, Jéssica B, Sato CS, Iguatemy Lourenço B, Maria Virgínia S, Gislaine Ricci L, Friberg SE, Chorilli M. Topical application of retinyl palmitate-based drug delivery systems for the treatment of skin aging. Biomed Res Int. 2016;2014:632570, Article ID 632570, 7 pages.

    Google Scholar 

  • Orentreich DS, Orentreich N. Subcutaneous incisionless (subcision) surgery for the correction of depressed scars and wrinkles. Dermatol Surg. 1995;21:6543–9.

    Google Scholar 

  • Palma SD. Potential use of ascorbic acid-based surfactants as skin penetration enhancers. Drug Dev Ind Pharm. 2006;32:821.

    CAS  CrossRef  PubMed  Google Scholar 

  • Park KY, Kim HK, Kim SE, Kim BJ, Kim MN. Treatment of striae distensae using needling therapy: a pilot study. Dermatol Surg. 2012;38:1823–8.

    Google Scholar 

  • Pavicic T. Complete biodegradable nature of calcium hydroxylapatite after injection for malar enhancement: an MRI study. Clin Cosmet Investig Dermatol. 2015;8:19–25.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Petchsangsai M, Rojanarata T, Opanasopit P, Ngawhirunpat T. The combination of microneedles with electroporation and sonophoresis to enhance hydrophilic macromolecule skin penetration. Biol Pharm Bull. 2014;37(8):1373–82.

    CAS  CrossRef  PubMed  Google Scholar 

  • Pistor M. Un defi therapeutiche: la mesotherapie. 3rd ed. Paris: Maloine; 1979. p. 1–50.

    Google Scholar 

  • Prausnitz MR. Microneedles for transdermal drug delivery. Advanced Drug Delivery Rev. 2004;56:581–7.

    CAS  CrossRef  Google Scholar 

  • Ro J, Kim Y, Kim H, Park K, Lee K-E, Khadka P, Yun G, Park J, Tai Chang S, Lee J, Jeong JH, Lee J. Pectin micro- and nano-capsules of retinyl palmitate as cosmeceutical carriers for stabilized skin transport. Korean J Physiol Pharmacol. 2015;19:59–64.

    Google Scholar 

  • Rosdahl I. Vitamin A metabolism and mRNA expression of retinoid-binding protein and receptor genes in human epi- dermal melanocytes and melanoma cells. Melanoma Res. 1997;7:267.

    CAS  CrossRef  PubMed  Google Scholar 

  • Ruszczak Z. Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev. 2003;55:1595.

    CAS  CrossRef  PubMed  Google Scholar 

  • Satish D. Microneedling with Dermaroller. J Cutan Aesthet Surg. 2009;2(2):65.

    CrossRef  Google Scholar 

  • Singh G, Kumar LP. Striae distensae. Indian J Dermatol Venereol Leprol. 2005;71:370–2.

    CrossRef  PubMed  Google Scholar 

  • Soltani-Arabshahi R, et al. Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation. JAMA Dermatol. 2014;150(1):68–72.

    CrossRef  PubMed  Google Scholar 

  • Sonker A, Dubey A, Bhatnagar A, Chaudhary R. Platelet growth factors from allogeneic platelet-rich plasma for clinical improvement in split-thickness skin graft. Asian J Transfus Sci. 2015;9(2):155–8. https://doi.org/10.4103/0973-6247.162712.

    CAS  CrossRef  PubMed  PubMed Central  Google Scholar 

  • Stamford NP. Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives. J Cosmet Dermatol. 2012;11(4):310–7.

    CrossRef  PubMed  Google Scholar 

  • Suh DH, Chang KY, Son HC, et al. Radiofrequency and 585-nm pulsed dye laser treatment of striae distensae: a report of 37 Asian patients. Dermatol Surg. 2007;33:29–34.

    CAS  PubMed  Google Scholar 

  • Tejero-Trujeque R. Understanding the final stages of wound contraction. J Wound Care. 2001;10:259.

    CAS  CrossRef  PubMed  Google Scholar 

  • Tran KT. Extracellular matrix signaling through growth factor receptors during wound healing. Wound Repair Regen. 2004;12:262.

    CrossRef  PubMed  Google Scholar 

  • Widgerow A. Bioengineered matrices Part 2: focal adhesion, integrins, and the fibroblast effect. Ann Plast Surg. 2012;68(6):574.

    CAS  CrossRef  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinica Vida – Cosmetic, Laser and Mohs Surgery Center, RUA DR VEIGA FILHO 350, 01229000, São Paulo, Brazil

    Gabriela Casabona & Paula Barreto Marchese

Authors
  1. Gabriela Casabona
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paula Barreto Marchese
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gabriela Casabona .

Editor information

Editors and Affiliations

  1. Department of Clinical Medicine – Dermatology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

    Ph.D. Maria Claudia Almeida Issa

  2. Clínicas Hospital of São Paulo of the University of Sao Paulo, Sao Paulo, São Paulo, Brazil

    Ph.D. Bhertha Tamura

Rights and permissions

Reprints and Permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Verify currency and authenticity via CrossMark

Cite this entry

Casabona, G., Marchese, P.B. (2018). Microneedling for Transepidermal Drug Delivery on Stretch Marks. In: Issa, M., Tamura, B. (eds) Lasers, Lights and Other Technologies. Clinical Approaches and Procedures in Cosmetic Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-16799-2_38

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-16799-2_38

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-16798-5

  • Online ISBN: 978-3-319-16799-2

  • eBook Packages: MedicineReference Module Medicine