Microneedling for Transepidermal Drug Delivery on Stretch Marks

Reference work entry
Part of the Clinical Approaches and Procedures in Cosmetic Dermatology book series (CAPCD)


Stretch marks (SMs) are a well-recognized, common skin condition that rarely cause any significant medical problems but are often a significant source of distress to those affected. The origins of SM are poorly understood, and a number of treatment modalities (Elsaie et al. 2009) are available for their treatment, yet none of them is consistently effective, and no single therapy is considered to be consensus for this problem. Multiple sittings of treatments such as chemical peelings, microdermabrasion, nonablative and ablative laser techniques, and light and radiofrequency devices are performed to improve the SM appearance. Microneedling and transepidermal drug delivery together are a new modality of treatment for SM. It is based on stimulation of collagen production and enhancement of the penetration of certain active substances across the skin with which it is possible to achieve satisfactory results.


Microneedling Transdermal drug delivery Transepidermal drug delivery Stretch marks Collagen 


  1. Al-Himdani S, Ud-Din S, Gilmore S, Bayat A. Striae distensae: a comprehensive review and evidence-based evaluation of prophylaxis and treatment. British J Dermatol. 2014;170:527–47.CrossRefGoogle Scholar
  2. Alster TS, Handrick C. Laser treatment of hypertrophic scars, keloids and striae. Semin Cutan Med Surg. 2000;19:287–92.CrossRefPubMedGoogle Scholar
  3. Alster TS, Handrick C. Laser treatment of scars and striae. In: Kuvar ANB, Hruza G, editors. Principles and in cutaneous laser surgery. New York: Marcel Decker; 2005. p. 625–41.Google Scholar
  4. Aust MC, Knobloch K, Reimers K, Redeker J, Ipaktchi R, Altintas ML, Gohritz A, Schwaiger N, Vogt PM. Percutaneous collagen induction therapy: an alternative treatment for burn scars. Burns. 2010;36(6):836–43.Google Scholar
  5. Aust M, et al. Percutaneous collagen induction therapy: an alternative treatment for scars, wrinkles, and skin laxity. Plast Reconst Surg. 2008;121(4):1421–9.CrossRefPubMedGoogle Scholar
  6. Berlin AL, Mussarratt H, Goldbergv DJ. Calcium hydroxylapatite filler for facial rejuvenation: a histologic and immunohistochemical analysis. Dermatol Surg. 2008;34:S64–7.Google Scholar
  7. Bernard FX. Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epi- dermis and normal human skin: transcriptional effects of retinoid treatments in reconstituted human epidermis. Exp Dermatol. 2002;11:59.CrossRefPubMedGoogle Scholar
  8. Brauer J, et al. Convergence of anatomy, technology, and therapeutics: a review of laser-assisted drug delivery. Semin Cutan Med Surg. 2014;33:176.CrossRefPubMedGoogle Scholar
  9. Budamakuntla L. A randomised, open-label, comparative study of tranexamic acid microinjections and tranexamic acid with microneedling in patients with melasma. J Cutan Aesthet Surg. 2013;6(3):139.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Camirand A, Doucet J. Needle dermabrasion. Aesthet Plast Surg. 1997;21:48–51.CrossRefGoogle Scholar
  11. Casabona G, Michalany N. Ultrasound with visualization and fillers for increased neocollagenesis: clinical and histological evaluation. Dermatol Surg. 2014;40:S194–8.Google Scholar
  12. Chawla S. Split face comparative study of microneedling with PRP versus microneedling with vitamin C in treating atrophic post acne scars. J Cutan Aesthet Surg. 2014;7(4):209–12.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Cho CW. In vitro characterization of the invasiveness of polymer microneedle against skin. Int J Pharm. 2010;397:201–5.CrossRefPubMedGoogle Scholar
  14. Elsaie ML MD, Baumann LS MD, Elsaaiee LT MD. Striae distensae (Stretch Marks) and different modalities of therapy: an update. Dermatol Surg. 2009;35:563–73.CrossRefPubMedGoogle Scholar
  15. Falabella AF, Falanga V. Wound healing. In: Feinkel RK, Woodley DT, editors. The biology of the skin. New York: Parthenon; 2000. p. 281–99.Google Scholar
  16. Faler BJ. Transforming growth factor-beta and wound healing. Perspect Vasc Surg Endovasc Ther. 2006;18:55.CrossRefPubMedGoogle Scholar
  17. Fat graft.Google Scholar
  18. Fenske NA. Structural and functional changes of normal aging skin. J Am Acad Dermatol. 1986;15:571.CrossRefPubMedGoogle Scholar
  19. Fernandes D. Percutaneous collagen induction: an alternative to laser resurfacing. Aesthetic Surg J. 2002;22:315.CrossRefGoogle Scholar
  20. Fernandes D. Minimally invasive percutaneous collagen induction. Oral Maxillofac Surg Clin North Am. 2006;17:51–63.CrossRefGoogle Scholar
  21. Fisher C. Retinoid receptors and keratinocytes. Crit Rev Oral Biol Med. 1995;6:284.CrossRefPubMedGoogle Scholar
  22. Gold MH MD. Noninvasive skin tightening treatment. J Clin Aesthet Dermatol. 2015;8(6):14–8.PubMedPubMedCentralGoogle Scholar
  23. Goldberg DJ, Marmur ES, Schmults C, Hussain M, Phelps R. Histologic and ultrastructural analysis of ultraviolet B laser and light source treatment of leukoderma in striae distensae. Dermatol Surg. 2005;31:385–7.CrossRefPubMedGoogle Scholar
  24. Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci. 1998;87:922–5. 33) Noh Y-W, Kim T-H, Baek J-S, Park H-H, Lee SS, Han M, Shin SC.CrossRefPubMedGoogle Scholar
  25. Ibrahim ZA1, El-Tatawy RA1, El-Samongy MA1, Ali DA2. Comparison between the efficacy and safety of platelet-rich plasma vs. microdermabrasion in the treatment of striae distensae: clinical and histopathological study. J Cosmet Dermatol. 2015;14:336.CrossRefPubMedGoogle Scholar
  26. Johnstone CC. The physiological basics of wound healing. Nurs Stand. 2005;19:59.CrossRefPubMedGoogle Scholar
  27. Kaushik S, Hord AH, Denson DD, McAllister DV, Smitra S, Allen MG, et al. Lack of pain associated with microfabricated microneedles. Anesth Analg. 2001;92:502–4.CrossRefPubMedGoogle Scholar
  28. Kumar V, Banga AK. Modulated iontophoretic delivery of small and large molecules through microchannels. Int J Pharm. 2012;434:106–14.CrossRefPubMedGoogle Scholar
  29. Lima E, Lima M, Takano D. Microneedling experimental study and classification of the resulting injury. Surg Cosmet Dermatol. 2013;5(2):110–4.Google Scholar
  30. Lynch SE. Growth factors in wound healing: single and synergistic effects on partial thickness porcine skin wounds. J Clin Invest. 1989;84:640.CrossRefPubMedPubMedCentralGoogle Scholar
  31. Majid I. Microneedling therapy in atrophic facial scars: an objective assessment. J Cutan Aesthet Surg. 2009;2:26–30.CrossRefPubMedPubMedCentralGoogle Scholar
  32. Martin P. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15:599.CrossRefPubMedGoogle Scholar
  33. McCrudden MTC, McAlister E, Courtenay AJ, Gonzalez-Vazquez P, Raghu T, Singh R, Donnelly RF. Microneedle applications in improving skin appearance. Exp Dermatol. 2015;24:561–6.CrossRefPubMedGoogle Scholar
  34. McDaniel D. Laser therapy of stretch marks. Dermatol Clinics. 2002;20(1):67–76.CrossRefGoogle Scholar
  35. Menon GK, Cleary GW, Lane ME. The structure and function of the stratum corneum. Int J Pharm. 2012;435:3–9.CrossRefPubMedGoogle Scholar
  36. Milewski M, Brogden NK, Stinchcomb AL. Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin. Expert Opin Drug Deliv. 2010;7:617–29.CrossRefPubMedPubMedCentralGoogle Scholar
  37. Nusgens BV. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol. 2001;116:853.CrossRefPubMedGoogle Scholar
  38. Oh JH, Kim W, Park KU, Roh YH. Comparison of the cellular composition and cytokine-release kinetics of various platelet-rich plasma preparations. Am J Sports Med. 2015;43:3062.Google Scholar
  39. Oliveira MB, Prado AHd, Jéssica B, Sato CS, Iguatemy Lourenço B, Maria Virgínia S, Gislaine Ricci L, Friberg SE, Chorilli M. Topical application of retinyl palmitate-based drug delivery systems for the treatment of skin aging. Biomed Res Int. 2016;2014:632570, Article ID 632570, 7 pages.Google Scholar
  40. Orentreich DS, Orentreich N. Subcutaneous incisionless (subcision) surgery for the correction of depressed scars and wrinkles. Dermatol Surg. 1995;21:6543–9.Google Scholar
  41. Palma SD. Potential use of ascorbic acid-based surfactants as skin penetration enhancers. Drug Dev Ind Pharm. 2006;32:821.CrossRefPubMedGoogle Scholar
  42. Park KY, Kim HK, Kim SE, Kim BJ, Kim MN. Treatment of striae distensae using needling therapy: a pilot study. Dermatol Surg. 2012;38:1823–8.Google Scholar
  43. Pavicic T. Complete biodegradable nature of calcium hydroxylapatite after injection for malar enhancement: an MRI study. Clin Cosmet Investig Dermatol. 2015;8:19–25.CrossRefPubMedPubMedCentralGoogle Scholar
  44. Petchsangsai M, Rojanarata T, Opanasopit P, Ngawhirunpat T. The combination of microneedles with electroporation and sonophoresis to enhance hydrophilic macromolecule skin penetration. Biol Pharm Bull. 2014;37(8):1373–82.CrossRefPubMedGoogle Scholar
  45. Pistor M. Un defi therapeutiche: la mesotherapie. 3rd ed. Paris: Maloine; 1979. p. 1–50.Google Scholar
  46. Prausnitz MR. Microneedles for transdermal drug delivery. Advanced Drug Delivery Rev. 2004;56:581–7.CrossRefGoogle Scholar
  47. Ro J, Kim Y, Kim H, Park K, Lee K-E, Khadka P, Yun G, Park J, Tai Chang S, Lee J, Jeong JH, Lee J. Pectin micro- and nano-capsules of retinyl palmitate as cosmeceutical carriers for stabilized skin transport. Korean J Physiol Pharmacol. 2015;19:59–64.Google Scholar
  48. Rosdahl I. Vitamin A metabolism and mRNA expression of retinoid-binding protein and receptor genes in human epi- dermal melanocytes and melanoma cells. Melanoma Res. 1997;7:267.CrossRefPubMedGoogle Scholar
  49. Ruszczak Z. Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev. 2003;55:1595.CrossRefPubMedGoogle Scholar
  50. Satish D. Microneedling with Dermaroller. J Cutan Aesthet Surg. 2009;2(2):65.CrossRefGoogle Scholar
  51. Singh G, Kumar LP. Striae distensae. Indian J Dermatol Venereol Leprol. 2005;71:370–2.CrossRefPubMedGoogle Scholar
  52. Soltani-Arabshahi R, et al. Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation. JAMA Dermatol. 2014;150(1):68–72.CrossRefPubMedGoogle Scholar
  53. Sonker A, Dubey A, Bhatnagar A, Chaudhary R. Platelet growth factors from allogeneic platelet-rich plasma for clinical improvement in split-thickness skin graft. Asian J Transfus Sci. 2015;9(2):155–8. Scholar
  54. Stamford NP. Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives. J Cosmet Dermatol. 2012;11(4):310–7.CrossRefPubMedGoogle Scholar
  55. Suh DH, Chang KY, Son HC, et al. Radiofrequency and 585-nm pulsed dye laser treatment of striae distensae: a report of 37 Asian patients. Dermatol Surg. 2007;33:29–34.PubMedGoogle Scholar
  56. Tejero-Trujeque R. Understanding the final stages of wound contraction. J Wound Care. 2001;10:259.CrossRefPubMedGoogle Scholar
  57. Tran KT. Extracellular matrix signaling through growth factor receptors during wound healing. Wound Repair Regen. 2004;12:262.CrossRefPubMedGoogle Scholar
  58. Widgerow A. Bioengineered matrices Part 2: focal adhesion, integrins, and the fibroblast effect. Ann Plast Surg. 2012;68(6):574.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Clinica Vida – Cosmetic, Laser and Mohs Surgery CenterSão PauloBrazil

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