Polysaccharides pp 1555-1582 | Cite as

Chemically Modified Natural Polysaccharides to Form Gels

  • John Garner
  • Kinam Park
Reference work entry


Polysaccharides have been utilized for a wide variety of industrial, cosmetic, food, and medical applications. The presence of functional groups on polysaccharides has been exploited for chemical modification to prepare polymers with unique properties. Various polysaccharides form hydrogels through physical or chemical cross-linking, and many of them possess environmentally responsive properties, known as smart hydrogels. Polysaccharide-based smart hydrogels are ideal for biomedical and pharmaceutical applications due to their inherent biocompatibility, degradability, and environment sensitivity, such as pH, temperature, and specific biomolecules.


Polysaccharides Chemical modification “Smart” hydrogels Chemically cross-linked Physically cross-linked 



This work was supported by the Showalter Research Trust Fund and the National Institutes of Health through CA129287 and GM095879.


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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Akina, Inc.West LafayetteUSA
  2. 2.Departments of Biomedical Engineering and Pharmaceutics, Weldon School of Biomedical EngineeringPurdue UniversityWest LafayetteUSA

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