Abstract
Freshwater and marine algae cover a wide group of various organisms living in diversified, terrestrial, or water habitats. Various environment conditions are important factors for the formation of many defense mechanisms to survive unfavorable climate leading to a wide scale of chemical compounds created by algae. Many of them show interesting and important biological activities with health benefits, which are the reason of algae being in the focus of scientists worldwide. Generally, algae can be considered as an abundant source of many nutrients, besides the polysaccharides, responsible for their different physicochemical properties with health beneficial effects. Fundamental seaweed polysaccharides with economic impact are presented by alginates, agars, carrageenans, ulvanes, and fucoidans used as a raw material mostly in the food and pharmaceutical industry. From medicinal point of view, especially sulfate polysaccharides are an important source of bioactive natural compounds exhibiting anticoagulant, antithrombotic, antitumor, antimicrobial, antimutagenic, anti-inflammatory, immunomodulatory, and antiviral activities. Thus, significant attention of this chapter has been focused on sulfate polysaccharides derived from algae with anticoagulant activities.
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Abd El Baky H, Hanaa El Baz KF, El-Latife SA (2013) Induction of sulfated polysaccharides in Spirulina platensis as response to nitrogen concentration and its biological evaluation. J Aquac Res Dev 5:1–8
Adams SS, Thorpe HM (1957) The anticoagulant activity and toxicity of laminarin sulphate K. J Pharm Pharmacol 9:459–463
Adelson E, Rheingold JJ, Parker O, Steiner M, Kirby JC (1963) The survival of factor VIII (antihemophilic globulin) and factor IX (plasma thromboplastin component) in normal humans. J Clin Invest 42:1040–1047
Aikawa S, Izumi Y, Matsuda F, Hasunuma T, Chang JS, Kondo A (2012) Synergistic enhancement of glycogen production in Arthrospira platensis by optimization of light intensity and nitrate supply. Bioresour Technol 108:211–215
Aquino RS, Grativol C, Mourão PAS (2011) Rising from the sea: correlations between sulfated polysaccharides and salinity in plants. Plos One 6:1–7
Arad SM, Levy-Ontman O (2010) Red microalgal cell-wall polysaccharides: biotechnological aspects. Curr Opin Biotechnol 21:358–364
Athucorala Y, Lee KW, Kim SK, Jeon YJ (2007) Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea. Bioresour Technol 98:1711–1716
Ball SG, Deschamps P (2009) Starch metabolism. In: Stern DB (ed) The chlamydomonas sourcebook: organellar and metabolic processes, 2nd edn. Academic/Elsevier, Oxford, pp 1–40
Becker EW (2007) Micro-algae as a source of protein. Biotechnol Adv 25:207–210
Bernardi G, Springer GF (1962) Properties of highly purified fucan. J Biol Chem 237:75–80
Berteau O, Mulloy B (2003) Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide. Glycobiology 13:29R–40R
Bick RL, Frenkel EP (1999) Clinical aspects of heparin-induced thrombocytopenia and thrombosis and other side effects of heparin therapy. Clin Appl Thromb Hemost 5:S7–S15
Bilan MI, Shashkov AS, Usov AI (2014) Structure of a sulfated xylofucan from the brown alga Punctaria plantaginea. Carbohydr Res 393:1–8
Blunt JW, Copp BR, Munro MHG, Northcote PT, Prinsep MR (2010) Marine natural products. Nat Prod Rep 27:165–237
Bouhlal R, Riadi H, Bourgougnon N (2010) Antiviral activity of the extract of Rhodophyceae from Morocco. Afr J Biotechnol 9:7968–7975
Burczyk J, Śmietana B, Termińska-Pabis K, Zych M, Kowalowski P (1999) Comparison of nitrogen content amino acid composition and glucosamine content of cell walls of various chlorococcalean algae. Phytochemistry 51:491–497
Cáceres PJ, Carlucci MJ, Damonte EB, Matsuhiro B, Zúniga EA (2000) Carrageenans from chilean samples of Stenogramme interrupta (Phyllophoraceae): structural analysis and biological activity. Phytochemistry 53:81–86
Carlucci MJ, Pujol CA, Ciancia M, Noseda MD, Matulewicz MC, Damonte EB, Cerezo AS (1997) Antiherpetic and anticoagulant properties of carrageenans from the red seaweed Gigartina skottsbergii and their cyclized derivatives: correlation between structure and biological activity. Int J Biol Macromol 20:97–105
Castelli R, Cassinerio E, Cappellini MD, Porro F, Graziadei G, Fabris F (2007) Heparin induced thrombocytopenia: pathogenic, clinical, diagnostic and therapeutic aspects. Cardiovasc Hematol Disord Drug Targets 7:153–162
Chandía NP, Matsuhiro B (2008) Characterization of a fucoidan from Lessonia vadosa (Phaeophyta) and its anticoagulant and elicitor properties. Int J Biol Macromol 42:235–240
Chao L, Bowen CC (1971) Purification and properties of glycogen isolated from a blue-green alga, Nostoc muscorum. J Bacteriol 105:331–338
Chatterjee MS, Denney WS, Jing H, Diamond SL (2010) Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood. Plos Comput Biol 6:1–24
Cheng YS, Zheng Y, Labavitch JM, Vander Gheynst JS (2011) The impact of cell wall carbohydrate composition on the chitosan flocculation of Chlorella. Process Biochem 46:1927–1933
Chevolot L, Mulloy B, Ratiskol J, Foucault A, Colliec-Jouault S (2001) A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae. Carbohydr Res 330:529–535
Ciferri O (1983) Spirulina, the edible microorganism. Microbiol Rev 47:551–578
Costa LS, Fidelis GP, Cordeiro SL, Oliviera RM, Sabry DA, Cãmara RBG, Nobre LTDB, Costa MSSP, Almeida-Lima J, Farias EHC, Leite EL, Rocha HAO (2010) Biological activities of sulfated polysaccharides from tropical seaweeds. Biomed Pharmacother 64:21–28
Cumashi A, Ushakova NA, Preobrazhenskaya ME, D’Incecco A, Piccoli A, Totani L, Tinari N, Morozevich GE, Berman AE, Bilan MI, Usov AI, Ustyuzhanina NE, Grachev AA, Sanderson CJ, Kelly M, Rabinovich GA, Iacobelli S, Nifantiev NE (2007) A comparative study of the anti-imflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology 17:541–552
Dahlbäck B, Villoutreix BO (2005) The anticoagulant protein C pathway. Febs Lett 579:3310–3316
Damonte E, Neyts J, Pujol CA, Snoeck R, Andrei G, Ikeda S, Witvrouw M, Reymen D, Haines H, Matulewitz MC, Cerezo A, Coto CE, De Clerco E (1994) Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata. Biochem Pharmacol 47:2187–2192
Dawczynski C, Schubert R, Jahreis G (2007) Amino acids, fatty acids, and dietary fibre in edible seaweed products. Food Chem 103:891–899
Deniaud E, Quemener B, Fleurence J, Lahaye M (2003) Structural studies of the mix-linked β-(1 → 3)/β-(1 → 4)-d-xylans from the cell wall of Palmaria palmata (Rhodophyta). Int Biol Macromol 33:9–18
De Ruiter GA, Rudolph B (1997) Carrageenan biotechnology. Trends Food Sci Tech 8:389–395
De Zoysa M, Nikapitiya C, Jeon YJ, Jee Y, Lee J (2008) Anticoagulant activity of sulfated polysaccharide isolated from fermented brown seaweed Sargassum fulvellum. J Appl Phycol 20:67–74
Dore CMPG, Alves MGCF, Will LSEP, Costa TG, Sabry DA, Souza Rego LAR, Accardo CM, Rocha HAO, Filgueira LGA, Leite EL (2013) A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and antiinflammatory effects. Carbohydr Polym 91:467–475
Dürig J, Bruhn T, Zurborn KH, Gutensohn K, Bruhn HD, Béress L (1997) Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 85:479–491
El Gamal AA (2010) Biological importance of marine algae. Saudi Pharm J 18:1–25
Esmon CT (2003) The protein C pathway. Chest 124:26S–32S
Esmon CT (2005) The interactions between inflammation and coagulation. Brit J Haematol 131:417–430
Farias WRL, Valente AP, Pereira MS, Mourão PAS (2000) Structure and anticoagulant activity of sulfated galactans. J Biol Chem 275:29299–29307
Fattah AFA, Hussein MMD, Salem HM (1974) Studies of the purification and some properties of sargassan, a sulphated heteropolysaccharide from sargassum linifolium. Carbohydr Res 33:9–17
Fenoradosoa TA, Ali G, Delattre C, Laroche C, Petit E, Wadouachi A, Michaud P (2010) Extraction and characterization of an alginate from the brown seaweed Sargassum turbinarioides Grunow. J Appl Phycol 22:131–137
Gretz MR, Aronson JM, Sommerfeld MR (1980) Cellulose in the cell wals of the bangiophyceae (rhodophyta). Science 207:779–781
Hayakawa Y, Hayashi T, Hayashi K, Ozawa T, Niiay K, Sakuragawa N (1997) Calcium spirulan as an inducer of tissue-type plasminogen activator in human fetal lung fibroblasts. Biochim Biophys Acta 1355:241–247
Hayakawa Y, Hayashi T, Lee JB, Ozawa T, Sakuragawa N (2000) Activation of heparin cofactor II by calcium spirulan. J Biol Chem 275:11379–11382
Hayakawa Y, Hirashima Y, Yamamoto H, Kurimoto M, Hayashi T, Lee JB, Endo S (2003) Mechanism of activation of heparin cofactor II by calcium spirulan. Arch Biochem Biophys 416:47–52
Hoffmann R, Paper DH, Donaldson J, Alban S, Franz G (1995) Characterization of a laminarin sulphate which inhibits basic fibroblast growth factor binding and andothelial cell proliferation. J Cell Sci 108:3591–3598
Holdt SL, Kraan S (2011) Bioactive compounds in seaweed: functional food applications and legislation. J Appl Phycol 23:543–597
Irhimeh MR, Fitton JH, Lowenthal RM (2009) Pilot clinical study to evaluate the anticoagulant activity of fucoidan. Blood Coagul Fibrinolysis 20:607–610
Iwao T, Kurashima A, Maegawa M (2008) Effect of seasonal changes in the photosynthates mannitol and laminaran on maturation of Ecklonia cava (Phaeophyceae, Laminariales) in Nishiki Bay, central Japan. Phycol Res 56:1–6
Jaulneau V, Lafitte C, Jacquet C, Fournier S, Salamagne S, Briand X, Esquerré-Tugayé MT, Dumas B (2010) Ulvan, a sulphated polysaccharide from green algae, activates plant immunity through the jasmonic acid signaling pathway. J Biomed Biotechnol 2010:1–11
Jiao G, Yu G, Zhang J, Ewart S (2011) Chemical structures and bioactivities of sulfated polysaccharides from marine algae. Mar Drugs 9:196–223
Jiménez-Escrig A, Sánchez-Muniz FJ (2000) Dietary fibre from edible seaweeds: chemical structure, physicochemical properties and effects on cholesterol metabolism. Nutr Res 20:585–598
Kalafatis M, Egan JO, van’t Veer C, Cawthern KM, Mann KG (1997) The regulation of clotting factors. Crit Rev Eukaryot Gene Expr 7:241–280
Karaki N, Sebaaly C, Chahine N, Faour T, Zinchenko A, Rachid S, Kanaan H (2013) The antioxidant and anticoagulant activities of polysaccharides isolated from the brown algae Dictyopteris polypodioides growing on the Lebanese coast. J Appl Pharm Sci 3:043–051
Karmakar P, Grosh T, Sinha S, Saha S, Mandal P, Ghosal PK, Ray B (2009) Polysaccharides from the brown seaweed Padina tetrastromatica: characterization of a sulfated fucan. Carbohydr Polym 78:416–421
Kim SK (2011) Marine medicinal foods: implications and applications, macro and microalgae. Academic, Burlington
Kolender AA, Pujol CA, Damonte EB, Matulewicz MC, Cerezo AS (1997) The system of sulfated α-(1 → 3)-linked d-mannans from the red seaweed Nothogenia fastigiata: structures, antiherpetic and anticoagulant properties. Carbohydr Res 304:53–60
Kroon-Batenburg LMJ, Kroon J (1997) EGC1 The crystal and molecular structures of cellulose I and II. Glycoconj J 14:677–690
Lahaye M (2001) Developments on gelling algal galactans, their structure and physico-chemistry. J Appl Phycol 13:173–184
Lahaye M, Brunel M, Bonnin E (1997) Fine chemical structure analysis of oligosaccharides produced by an ulvan-lyase degradation of the water-soluble cell-wall polysaccharides from Ulva sp. (Ulvales, Chlorophyta). Carbohydr Res 304:325–333
Laos K, Brownsey GJ, Friedenthal M, Ring SG (2005) Rheological properties of gels formed with furcellaran and globular proteins bovine serum albumin and β-lactoglobulin. Ann Trans Nord Rheol Soc 13:269–275
Laos K, Ring SG (2005) Characterisation of furcellaran samples from Estonian Furcellaria lumbricalis (Rhodophyta). J Appl Phycol 17:461–464
Larsen B, Salem DMSA, Sallam MAE, Mishrikey MM, Beltagy AI (2003) Characterization of the alginates from algae harvested at the Egyptian Red Sea coast. Carbohydr Res 338:2325–2336
Lee JB, Hayashi T, Hayashi K, Sankawa U (2000) Structural analysis of calcium spirulan (Ca-SP)-derived oligosaccharides using electrospray ionization mass spectrometry. J Nat Prod 63:136–138
Lee JB, Hayashi T, Hayashi K, Sankawa U, Maeda M (1998) Further purification and structural analysis of calcium spirulan from Spirulina platensis. J Nat Prod 61:1101–1104
Leite EL, Medeiros MGL, Rocha HAO, Farias GGM, da Silva LF, Chavante SF, de Abreu LD, Dietrich CP, Nader HB (1998) Structure and pharmacological activities of a sulfated xylofucoglucuronan from alga Spatoglossum schröederi. Plant Sci 132:215–228
Li B, Lu F, Wei X, Zhao R (2008) Fucoidan: structure and bioactivity. Molecules 13:1671–1695
MacArtain P, Gill CIR, Brooks M, Campbell R, Rowland IR (2007) Nutritional value of edible seaweeds. Nutr Rev 65:535–543
Majdoub H, Mansour MB, Chaubet F, Roudesli MS, Maaroufi RM (2009) Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis. Biochim Biophys Acta 1790:1377–1381
Mao WJ, Fang F, Li HY, Qi XH, Sun HH, Chen Y, Guo SD (2008) Heparinoid-active two sulfated polysaccharides isolated from marine green algae Monostroma nitidum. Carbohydr Polym 74:834–839
Mao W, Li H, Li Y, Zhang H, Qi X, Sun H (2009) Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta). Int J Biol Macromol 44:70–74
Mao W, Zang X, Li Y, Zhang H (2006) Sulfated polysaccharides from marine algae Ulva conglobata and their anticoagulant activity. J Appl Phycol 18:9–14
Marsham S, Scott GW, Tobin ML (2007) Comparison of nutritive chemistry of a range of temperate seaweeds. Food Chem 100:1331–1336
Matsubara K, Matsuura Y, Bacic A, Liao M, Hori K, Miyazawa K (2001) Anticoagulant properties of a sulfated galactan preparation from a marine green alga, Codium cylindricum. Int J Biol Macromol 28:395–399
McCracken DA, Cain JR (1981) Amylose in floridean starch. New Phytol 88:67–71
Miao HQ, Ishai MR, Peretz T, Vlodavsky I (1995) Laminarin sulfate mimics the effects of heparin on smooth muscle cell proliferation and basic fibroblast growth factor-receptor binding and mitogenic activity. J Cell Physiol 164:482–490
Miller IJ (1996) Alginate composition of some New Zealand brown seaweeds. Phytochemistry 41:1315–1317
Miller IJ, Falshaw R, Furneaux RH (1993) The chemical structure of the polysaccharide from Dasyclonium incisum. Hydrobiologia 260–261:647–651
Mirzaahmadi S, Asaadi-Tehrani G, Bandehpour M, Davouri N, Tahmasbi L, Hosseinzadeh N, Mirzahoseini H, Parivar K, Kazemi B (2011) Expression of recombinant human coagulation factor VII by the Lizard Leishmania expression system. J Biomed Biotechnol 2011:1–8
Mišurcová L (2011) Chemical composition of seaweeds. In: Kim SK (ed) Handbook of marine macroalgae: biotechnology and applied phycology, 1st edn. Wiley, Chichester, pp 173–192
Mišurcová L, Ambrožová J, Samek D (2011a) Seaweed lipids as nutraceuticals. In: Kim SK (ed) Advances in food and nutrition research, 1st edn. Academic, Burlington, pp 339–355
Mišurcová L, Buňka F, Vávra Ambrožová J, Machů L, Samek D, Kráčmar S (2014) Amino acid composition of algal products and its contribution to RDI. Food Chem 151:120–125
Mišurcová L, Machů L, Orsavová J (2011b) Seaweed minerals as nutraceuticals. In: Kim SK (ed) Advances in food and nutrition research, 1st edn. Academic, Burlington, pp 371–390
Mišurcová L, Škrovánková S, Samek D, Ambrožová J, Machů L (2012) Health benefits of algal polysaccharides in human nutrition. In: Henry J (ed) Advances in food and nutrition research, 1st edn. Academic, Burlington, pp 75–145
Myers AM, Morell MK, James MG, Ball SG (2000) Recent progress toward understanding biosynthesis of the amylopectin crystal. Plant Physiol 122:989–997
Nakamura Y, Takahashi JI, Sakurai A, Inaba Y, Suzuki E, Nihei S, Fujiwara S, Tsuzuki M, Miyashita H, Ikemoto H, Kawachi M, Sekiguchi H, Kurano N (2005) Some cyanobacteria synthesize semi-amylopectin type α-polyglucans instead of glycogen. Plant Cell Physiol 46:539–545
Nie ZY, Xia JL, Levert JM (2002) Fractionation and characterization of polysaccharides from cyanobacterium Spirulina (Arthrospira) maxima in nitrogen-limited batch culture. J Cent South Univ Technol 9:81–86
Nishiyama Y, Sugiyama J, Chanzy H, Langan P (2003) Crystal structure and hydrogen bonding system in cellulose I α from synchrotron X-ray and neutron fiber diffraction. J Am Chem Soc 125:14300–14306
Ogbonda KH, Aminigo RE, Abu GO (2007) Influence of aeration and lighting on biomass production and protein biosynthesis in a Spirulina sp. isolated from an oil-polluted brackish water marsh in the Niger Delta, Nigeria. Afr J Biotechnol 6:2596–2600
Padmanaban VC, Prashant KP, Ranjith MV, Aswani T, Aswani MT (2013) Comparative analysis of anti-coagulant potential of marine macro algae. Int J Pharm Pharm Sci 5:334–337
Patankar MS, Oehninger S, Barnett T, Williams RL, Clark GF (1993) A revised structure for fucoidan may explain some of its biological activities. J Biol Chem 268:21770–21776
Patron NJ, Keeling PJ (2005) Common evolutionary origin of starch biosynthetic enzymes in green and red algae. J Phycol 41:1131–1141
Percival E (1979) The polysaccharides of green, red and brown seaweeds: their basic structure, biosynthesis and function. Br Phycol J 14:103–107
Percival E, McDowel RH (1967) Chemistry and enzymology of marine algal polysaccharides. Academic, London
Pereira MG, Benevides NMB, Melo MRS, Valente AP, Melo FR, Mourão PAS (2005) Structure and anticoagulant activity of a sulfated galactan from the red alga, Gelidium crinale. Is there a specific structural requirement for the anticoagulant action? Carbohydr Res 340:2015–2023
Pereira MS, Melo FR, Mourão PAS (2002) Is there a correlation between structure and anticoagulant action of sulfated galactans and sulfated fucans? Glycobiology 12:573–580
Pereira MS, Mulloy B, Mourão PAS (1999) Structure and anticoagulant activity of sulfated fucans. J Biol Chem 274:7656–7667
Pomin VH, Mourão PAS (2008) Structure, biology, evolution, and medical importance of sulfated fucans and galactans. Glycobiology 18:1016–1027
Pomin VH, Pereira MS, Valente A, Tollefsen DM, Pavão MSG, Mourão PAS (2005) Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II–dependent anticoagulant activity. Glycobiology 15:369–381
Popper Z, Tuohy MG (2010) Beyond the green: understanding the evolutionary puzzle of plant and algal cell walls. Plant Physiol 153:373–383
Praiboon J, Chirapart A, Akakabe Y, Bhumibhamon O, Kajiwara T (2006) Physical and chemical characterization of agar polysaccharides extracted from the Thai and Japanese species of Gracilaria. Science Asia 32:11–17
Pushpamali WA, Nikapitiya C, De Zoysa M, Whang I, Kim SJ, Lee J (2008) Isolation and purification of an anticoagulant from fermented red seaweed Lomentaria catenata. Carbohydr Polym 73:274–279
Qi X, Mao W, Gao Y, Chen Y, Zhao C, Li N, Wang C, Yan M, Lin C, Shan J (2012) Chemical characteristic of an anticoagulant-active sulfated polysaccharide from Enteromorpha clathrata. Carbohydr Polym 90:1804–1810
Rao LV, Nordfang O, Hoang AD, Pendurthi UR (1995) Mechanism of antithrombin III inhibition of factor VIIa/tissue factor activity on cell surfaces. Comparison with tissue factor pathway inhibitor/factor Xa-induced inhibition of factor VII/a tissue factor activity. Blood 1:121–129
Rees DA, Convay E (1962) The structure and biosynthesis of porphyran: a comparison of some samples. Biochem J 84:411–416
Rioux LE, Turgeon SL, Beaulieu M (2007) Characterization of polysaccharides extracted from brown seaweeds. Carbohydr Polym 69:530–537
Rocha HAO, Moraes FA, Trindade ES, Franco CRC, Torquato RJS, Veiga SS, Valente AP, Mourão PAS, Leite EL, Nader HB, Dietrich CP (2005) Structural and hemostatic activities of a sulfated galactofucan from the brown alga Spatoglossum schroederi. J Biol Chem 280:41278–41288
Rodrigues JAG, Quinderé ALG, de Queiroz INL, Coura CO, Benevides NMB (2012) Comparative study of sulfated polysaccharides from Caulerpa spp. (Chlorophyceae). Biotechnological tool for species identification? Maringá 34:381–389
Rodrigues JAG, Vanderlei ESO, Bessa ÉF, Magalhaes FA, de Paula RCM, Lima V, Benevides NMB (2011) Anticoagulant activity of a sulfated polysaccharide isolated from the green seaweed Caulerpa cupressoides. Braz Arch Biol Techn 54:691–700
Rodrigues MA, da Silva Bon EP (2011) Evaluation of Chlorella (Chlorophyta) as source of fermentable sugars via cell wall enzymatic hydrolysis. Enzym Res 2011:1–5
Rupérez P, Ahrazem O, Leal JA (2002) Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus. J Agric Food Chem 50:840–845
Rupérez P, Toledano G (2003) Indigestible fraction of edible marine seaweeds. J Sci Food Agric 83:1267–1272
Sartal CG, Alonso MCB, Barrera PB (2011) Application of seaweeds in the food industry. In: Kim SK (ed) Handbook of marine macroalgae: biotechnology and applied phycology, 1st edn. Wiley, Chichester, pp 522–531
Sebaaly C, Kassem S, Grishina E, Kanaan H, Sweidan A, Chmit MS, Kanaan HM (2014) Anticoagulant and antibacterial activities of polysaccharides of red algae Corallina collected from Lebanese coast. J Pharm Sci 4:030–037
Sen AKSR, Das AK, Banerji N, Siddhanta AK, Mody KH, Ramavat BK, Chauhan VD, Vedasiromoni JR, Ganguly DK (1994) A new sulfated polysaccharide with potent blood anti-coagulant activity from the red seaweed Grateloupia indica. Int J Biol Macromol 16:279–280
Shanmugam M, Mody KH (2000) Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant. Curr Sci India 79:1672–1683
Shanmugam M, Mody KH, Ramavat BK, Murthy ASK, Siddhanta AK (2002) Screening of Codiacean algae (Chlorophyta) of the Indian coasts for blood anticoagulant activity. Indian J Mar Sci 31:33–38
Shi Y, Sheng J, Yang F, Hu Q (2007) Purification and identification of polysaccharide derived from Chlorella pyrenoidosa. Food Chem 103:101–105
Shimonaga T, Fujiwara S, Kaneko M, Izumo A, Nihei S, Francisko PB, Satoh A, Fujita N, Nakamura Y, Tsuzuki M (2007) Variation in storage α-polyglucans of red algae: amylose and semi-amylopectin types in Porphyridium and glycogen type in Cyanidium. Mar Biotechnol 9:192–202
Silva TH, Alves A, Popa EG, Reys LL, Gomes ME, Sousa RA, Silva SS, Mano JF, Reis RL (2010) Marine algae sulfated polysaccharides for tissue engineering and drug delivery approaches. Biomatter 2:1–12
Silva TMA, Alves LG, de Queiroz KCS, Santos MGL, Marques CT, Chavante SF, Rocha HAO, Leite EL (2005) Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora. Braz J Med Biol Res 38:523–533
Spronk HMH, Govers-Riemslag JWP, ten Cate H (2003) The blood coagulation system as a molecular machine. Bioessays 256:1220–1228
Streusand VJ, Björk I, Gettins PGW, Petitou M, Olson ST (1995) Mechanism of acceleration of antithrombin-proteinase reactions by low affinity heparin. J Biol Chem 270:9043–9051
Takeda H (1996) Cell wall sugars of some Scenedesmus species. Phytochemistry 42:673–675
Thuy TTT, Ly BM, Van TTT, Quang NV, Tu HC, Zheng Y, Seguin-Devaux C, Mi B, Ai U (2015) Anti-HIV activity of fucoidans from three brown seaweed species. Carbohydr Polym 115:122–128
Ushakova NA, Morozevich GE, Ustyuzhanina NE, Bilan MI, Usov AI, Nifantiev NE, Preobrazhenskaya ME (2009) Anticoagulant activity of fucoidans from brown algae. Biochem Moscow 3:77–83
Usov AI (1998) Structural analysis of red seaweed galactans of agar and carrageenan groups. Food Hydrocoll 12:301–308
Usov AI, Smirnova GP, Klochkova NG (2001) Polysaccharides of algae: 55.1 polysaccharide composition of several brown algae from kamchatka. Russ J Bioorg Chem 27:395–399
Viola R, Nyvall P, Pedersén M (2001) The unique features of starch metabolism in red algae. Proc R Soc Lond B 268:1417–1422
Wang X, Zhang Z, Yao Z, Zhao M, Qi H (2013) Sulfation, anticoagulant and antioxidant activities of polysaccharide from green algae Enteromorpha linza. Int J Biol Macromol 58:225–230
Warrand J (2006) Healthy polysaccharides. The next chapter in food products. Food Technol Biotechnol 44:355–370
Wijesekara I, Pangestutti R, Kim SK (2011) Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae. Carbohydr Polym 84:14–21
Wijesinghe WAJP, Athukorala Y, Jeon YJ (2011) Effect of anticoagulative sulfated polysaccharide purified from enzyme-assistant extract of a brown seaweed Ecklonia cava on Wistar rats. Carbohydr Polym 86:917–921
Wijesinghe WAJP, Jeon YJ (2012) Biological activities and potential industrial applications of fucose rich polysaccharides and fucoidans isolated from brown seaweeds: a review. Carbohydr Polym 88:13–20
Yamada T, Sakaguchi K (1982) Comparative studies on Chlorella cell walls: induction of protoplast formation. Arch Microbiol 132:10–13
Yamamoto C, Nakamura A, Shimada S, Kaji T, Lee JB, Hayashi T (2003) Differential effects of sodium spirulan on the secretion of fibrinolytic proteins from vascular endothelial cells: enhancement of plasminogen activator activity. J Health Sci 49:405–409
Ye H, Wang K, Zhou C, Liu J, Zeng X (2008) Purification, antitumor and antioxidant activities in vitro of polysaccharides from the brown seaweed Sargassum pallidum. Food Chem 111:428–432
Yermak IM, Barabanova AO, Glazunov VP, Isakov VV, Hwan KY, Soon SK, Titlynova TV, Solov’eva TF (2006) Carrageenans from cystocarpic and sterile plants of Chondrus pinnulatus (Gigartinaceae, Rhodophyta) collected from the Russian Pacific coast. J Appl Phycol 18:361–368
Zhang HJ, Mao WJ, Fang F, Li HY, Sun HH, Chen Y, Qi XH (2008) Chemical characteristics and anticoagulant activities of a sulfated polysaccharide and its fragments from Monostroma latissimum. Carbohydr Polym 71:428–434
Zhang Z, Zhang Q, Wang J, Song H, Zhang H, Niu X (2010) Regioselective syntheses of sulfated porphyrans from Porphyra haitanensis and their antioxidant and anticoagulant activities in vitro. Carbohydr Polym 79:1124–1129
Zúniga EA, Matsuhiro B, Mejías E (2006) Preparation of a low-molecular weight fraction by free radical depolymerization of the sulfated galactan from Schizymenia binderi (Gigartinales, Rhodophyta) and its anticoagulant activity. Carbohydr Polym 66:208–215
Zvyagintseva TN, Shevchenko NM, Nazarenko EL, Gorbach VI, Urvantseva AM, Kiseleva MI, Isakov VV (2005) Water-soluble polysaccharides of some brown algae of the Russian Far-East. Structure and biological action of low-molecular mass polyuronans. J Exp Mar Biol Ecol 320:123–131
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Mišurcová, L., Orsavová, J., Ambrožová, J.V. (2015). Algal Polysaccharides and Health. In: Ramawat, K., Mérillon, JM. (eds) Polysaccharides. Springer, Cham. https://doi.org/10.1007/978-3-319-16298-0_24
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DOI: https://doi.org/10.1007/978-3-319-16298-0_24
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