Encyclopedia of Bioastronautics

Living Edition
| Editors: Laurence R. Young, Jeffrey P. Sutton

Space Radiation Effects on the Cardiovascular System

  • Marjan BoermaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-10152-1_83-1

Definition

While the Earth’s magnetic fields protect astronauts against some of the radiation in space when in the International Space Station, future long-distance space travel beyond low-Earth orbit will lead to exposures to ionizing radiation at higher doses and over longer periods of time. Ground-based epidemiological studies have indicated that the cardiovascular system is relatively sensitive to ionizing radiation, and this has raised the concern of a cardiovascular disease risk from exposure to radiation in space. However, we should keep in mind that biological effects of space radiation can be different from the effects of common forms of ionizing radiation on Earth, and therefore, health risks of space radiation need to be carefully assessed. Ground-based studies with animal and cell culture models play an important role in estimating these risks. We here provide an overview of these experimental studies that have started to address the cardiovascular effects of space...

This is a preview of subscription content, log in to check access.

References

  1. Akleyev AV (2014) Chronic radiation syndrome. Springer, Berlin/HeidelbergCrossRefGoogle Scholar
  2. Boerma M, Nelson GA, Sridharan V, Mao XW, Koturbash I, Hauer-Jensen M (2015) Space radiation and cardiovascular disease risk. World J Cardiol 7:882–888. Under ReviewCrossRefGoogle Scholar
  3. Committee on the Evaluation of Radiation Shielding for Space Exploration, National Research Council (2008) Managing space radiation risk in the new era of space exploration. The National Academies Press, Washington, DCGoogle Scholar
  4. Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation, National Research Council (2006) Health risks from exposure to low levels of ionizing radiation: BEIR VII phase 2. The National Academies Press, Washington, DCGoogle Scholar
  5. Cucinotta FA, Wu H, Shavers MR, George K (2003) Radiation dosimetry and biophysical models of space radiation effects. Gravit Space Biol Bull 16:11–18Google Scholar
  6. Ewer MS, Yeh ETH (2013) Cancer and the heart. People’s Medical Publishing House-USA, SheltonGoogle Scholar
  7. Fajardo LF, Berthrong M, Anderson RE (2001) Radiation pathology. Oxford University Press, New YorkGoogle Scholar
  8. Hall EJ, Giaccia AJ (2012) Radiobiology for the radiologist, 7nd edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  9. Kennedy AR (2014) Biological effects of space radiation and development of effective countermeasures. Life Sci Space Res 1:10–43CrossRefGoogle Scholar
  10. Rubin DB (1997) The radiation biology of the vascular endothelium. CRC Press LLC, Boca RatonGoogle Scholar
  11. Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, MacVittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH (2010) Animal models for medical countermeasures to radiation exposure. Radiat Res 173:557–578CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.University of Arkansas for Medical Sciences (Univ of Arkansas for Med Sci)Little RockUSA

Section editors and affiliations

  • Kathryn D. Held
    • 1
  1. 1.Radiation OncologyMassachusetts General Hospital/Harvard Medical SchoolBostonUSA