Skip to main content

The Reward Deficiency Syndrome and Links with Addictive and Related Behaviors

  • Living reference work entry
  • First Online:
Handbook of Substance Misuse and Addictions

Abstract

There are multiple theoretical and empirical attempts to capture the shared routes of different substance-use disorders and other disorders due to addictive behaviors, thus conceptually integrating the conditions. One is the reward deficiency syndrome (RDS) model that provides a biopsychological framework for addictions. The RDS model argues that individuals with hypodopaminergic features need extra external stimulation to achieve positive feelings like satisfaction or pleasure. The model argues that the hypodopaminergic features are predisposed by genetic factors that are responsible for dopamine homeostasis. While there exists some support for the model, further systematic studies are needed to validate it. This chapter describes the key constructs of the RDS model and discusses their potential implications for addictions while also acknowledging possible critiques and weaknesses.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Abbreviations

ADHD:

Attention-deficit hyperactivity disorder

DRD3 :

A gene coding the dopamine receptor D3 protein

DRD4 :

A gene coding the dopamine receptor D4 protein

DSM-5:

Diagnostic and Statistical Manual for Mental Disorders (American Psychiatric Association 2013)

GABAR3 :

A gene coding the gamma-amino-butyric acid receptor subunit beta-3 protein

GARS:

Genetic Addiction Risk Score

5-HTTLPR:

A variable number tandem repeat (VNTR) polymorphism of the SLC6A4 gene, coding serotonin transporter

ICD-11:

International Classification of Diseases (World Health Organization 2018)

PTSD:

Post-traumatic stress disorder

RDS:

Reward deficiency syndrome

RDSQ:

Reward Deficiency Syndrome Questionnaire

DRD2 :

A gene coding the dopamine receptor D2 protein

References

  • Agrawal A, Verweij KJH, Gillespie NA, Heath AC, Lessov-Schlaggar CN, Martin NG et al (2012) The genetics of addiction – a translational perspective. Transl Psychiatry 2(7):e140–e140

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn, Washington, DC

    Google Scholar 

  • Andreassen CS, Billieux J, Griffiths M, Kuss DJ, Demetrovics Z, Mazzoni E et al (2016) The relationship between addictive use of social media and video games and symptoms of psychiatric disorders: a large-scale cross-sectional study. Psychol Addict Behav 30(2):252

    Article  Google Scholar 

  • Benton D, Young HA (2016) A meta-analysis of the relationship between brain dopamine receptors and obesity: a matter of changes in behavior rather than food addiction? Int J Obes 40(1):S12–S21

    Article  CAS  Google Scholar 

  • Berggren U, Fahlke C, Aronsson E, Karanti A, Eriksson M, Blennow K et al (2006) The taqI DRD2 A1 allele is associated with alcohol-dependence although its effect size is small. Alcohol Alcohol 41(5):479–485

    Article  CAS  PubMed  Google Scholar 

  • Bidwell LC, Knopik VS, Audrain-Mcgovern J, Glynn TR, Spillane NS, Ray LA et al (2015) Novelty seeking as a phenotypic marker of adolescent substance use. Subst Abus 9s1:SART.S22440

    Google Scholar 

  • Blomqvist O, Gelernter J, Kranzler HR (2000) Family-based study of DRD2 alleles in alcohol and drug dependence. Am J Med Genet 96(5):659–664

    Article  CAS  PubMed  Google Scholar 

  • Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P et al (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263(15):2055–2060

    Article  CAS  PubMed  Google Scholar 

  • Blum K, Sheridan PJ, Wood R, Braverman E (1994) Utilization of Bayes’ theorem to estimate the predictive value of the A1 allele of the D2 dopamine receptor gene in compulsive disease. Neuropsychopharmacology 11(4):266–266

    Article  Google Scholar 

  • Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Comings DE (1995a) Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Pharmacogenetics 5(3):121–141

    Article  CAS  PubMed  Google Scholar 

  • Blum K, Wood RC, Braverman ER, Chen TJ, Sheridan PJ (1995b) The D2 dopamine receptor gene as a predictor of compulsive disease: Bayes’ theorem. Funct Neurol 10(1):37–44

    CAS  PubMed  Google Scholar 

  • Blum K, Cull J, Braverman E, Comings D (1996a) Reward deficiency syndrome. Am Sci 84(2):132–145

    Google Scholar 

  • Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Cull JG et al (1996b) The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J R Soc Med 89(7):396–400

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blum K, Febo M, McLaughlin T, Cronje FJ, Han D, Gold SM (2014a) Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS) as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric. J Behav Addict 3(3):149–156

    Article  PubMed  PubMed Central  Google Scholar 

  • Blum K, Oscar-Berman M, Demetrovics Z, Barh D, Gold MS (2014b) Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS). Mol Neurobiol 50(3):765–796

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blum K, Febo M, Badgaiyan RD, Demetrovics Z, Simpatico T, Fahlke C et al (2017) Common neurogenetic diagnosis and meso-limbic manipulation of hypodopaminergic function in reward deficiency syndrome (RDS): changing the recovery landscape. Curr Neuropharmacol 15(1):184–194

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blum K, Gondré-Lewis MC, Baron D, Thanos PK, Braverman ER, Neary J et al (2018) Introducing precision addiction Management of Reward Deficiency Syndrome, the construct that underpins all addictive behaviors. Front Psych 9:548–548

    Article  Google Scholar 

  • Brand M, Young KS, Laier C, Wölfling K, Potenza MN (2016) Integrating psychological and neurobiological considerations regarding the development and maintenance of specific internet-use disorders: an interaction of person-affect-cognition-execution (I-PACE) model. Neurosci Biobehav Rev 71:252–266

    Article  PubMed  Google Scholar 

  • Brand M, Rumpf HJ, Demetrovics Z, Müller A, Stark R, King D, L., et al. (in press) Which conditions should be considered as disorders in the ICD-11 designation of “other specified disorders due to addictive behaviors”? J Behav Addict

    Google Scholar 

  • Chen TJ, Blum K, Chen AL, Bowirrat A, Downs WB, Madigan MA et al (2011) Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by a neuroadaptagen: proposing an addiction candidate gene panel map. J Psychoactive Drugs 43(2):108–127

    Article  PubMed  Google Scholar 

  • Demetrovics Z, Griffiths MD (2012) Behavioral addictions: past, present and future. J Behav Addict 1(1):1–2

    Article  PubMed  Google Scholar 

  • Dick DM (2016) The genetics of addiction: where do we go from here? J Stud Alcohol Drugs 77(5):673–675

    Article  PubMed  Google Scholar 

  • Dodd ML, Klos KJ, Bower JH, Geda YE, Josephs KA, Ahlskog JE (2005) Pathological gambling caused by drugs used to treat Parkinson disease. Arch Neurol 62(9):1377–1381

    Article  PubMed  Google Scholar 

  • Ersche KD, Turton AJ, Pradhan S, Bullmore ET, Robbins TW (2010) Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits. Biol Psychiatry 68(8):770–773

    Article  PubMed  PubMed Central  Google Scholar 

  • Foll BL, Gallo A, Strat YL, Lu L, Gorwood P (2009) Genetics of dopamine receptors and drug addiction: a comprehensive review. Behav Pharmacol 20(1):1–17

    Article  PubMed  Google Scholar 

  • Garfield JBB, Lubman DI, Yücel M (2014) Anhedonia in substance use disorders: a systematic review of its nature, course and clinical correlates. Aust N Z J Psychiatry 48(1):36–51

    Article  PubMed  Google Scholar 

  • Gelernter J, Kranzler H (1999) D2 dopamine receptor gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype. Neuropsychopharmacology 20(6):640–649

    Article  CAS  PubMed  Google Scholar 

  • Gendreau KE, Potenza MN (2014) Detecting associations between behavioral addictions and dopamine agonists in the Food & Drug Administration’s adverse event database. J Behav Addict 3(1):21–26

    Article  PubMed  PubMed Central  Google Scholar 

  • Gendreau KE, Potenza MN (2016) Publicity and reports of behavioral addictions associated with dopamine agonists. J Behav Addict 5(1):140–143

    Article  PubMed  Google Scholar 

  • Gerrard M, Gibbons FX, Houlihan AE, Stock ML, Pomery EA (2008) A dual-process approach to health risk decision making: the prototype willingness model. Dev Rev 28(1):29–61

    Article  Google Scholar 

  • Goldstein RZ, Volkow ND (2002) Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 159(10):1642–1652

    Article  PubMed  PubMed Central  Google Scholar 

  • Gorwood P, Batel P, Gouya L, Courtois F, Feingold J, Adès J (2000) Reappraisal of the association between the DRD2 gene, alcoholism and addiction. Eur Psychiatry 15(2):90–96

    Article  CAS  PubMed  Google Scholar 

  • Grant JE, Chamberlain SR (2014) Impulsive action and impulsive choice across substance and behavioral addictions: cause or consequence? Addict Behav 39(11):1632–1639

    Article  PubMed  Google Scholar 

  • Grant JE, Potenza MN, Weinstein A, Gorelick DA (2010) Introduction to behavioral addictions. Am J Drug Alcohol Abuse 36(5):233–241

    Article  PubMed  PubMed Central  Google Scholar 

  • Griffiths M (2005) A ‘components’ model of addiction within a biopsychosocial framework. J Subst Abus 10(4):191–197

    Google Scholar 

  • Griffiths M, Wardle H, Orford J, Sproston K, Erens B (2010) Gambling, alcohol, consumption, cigarette smoking and health: findings from the 2007 British gambling prevalence survey. Addict Res Theory 18(2)

    Google Scholar 

  • Hofmann W, Friese M, Strack F (2009) Impulse and self-control from a dual-systems perspective. Perspect Psychol Sci 4(2):162–176

    Article  PubMed  Google Scholar 

  • Ikemoto S (2010) Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory. Neurosci Biobehav Rev 35(2):129–150

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ioannidis K, Hook R, Goudriaan AE, Vlies S, Fineberg NA, Grant JE et al (2019) Cognitive deficits in problematic internet use: meta-analysis of 40 studies. Br J Psychiatry 1–8

    Google Scholar 

  • Kotyuk E, Magi A, Eisinger A, Király O, Vereczkei A, Barta C et al (2020) Co-occurrences of substance use and other potentially addictive behaviors: epidemiological results from the psychological and genetic factors of the addictive behaviors (PGA) study. J Behav Addict 9(2):272–288

    Article  PubMed  Google Scholar 

  • Kótyuk E, Urbán R, Hende B, Richman M, Magi A, Király O, et al (in press) The development and validation of the Reward Deficiency Syndrome Questionnaire (RDSQ-29)

    Google Scholar 

  • Leyton M (2014) What’s deficient in reward deficiency? J Psychiatry Neurosci 39(5):291–293

    Article  PubMed  PubMed Central  Google Scholar 

  • Luijten M, Machielsen MW, Veltman DJ, Hester R, de Haan L, Franken IH (2014) Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people with substance dependence and behavioural addictions. J Psychiatry Neurosci 39(3):149–169

    Article  PubMed  PubMed Central  Google Scholar 

  • MacKillop J, Munafò MR (2013) Genetic influences on addiction: an intermediate phenotype approach. The MIT Press, Cambridge, MA

    Book  Google Scholar 

  • Marmet S, Studer J, Wicki M, Bertholet N, Khazaal Y, Gmel G (2019) Unique versus shared associations between self-reported behavioral addictions and substance use disorders and mental health problems: a commonality analysis in a large sample of young Swiss men. J Behav Addict 8(4):664–677

    Article  PubMed  PubMed Central  Google Scholar 

  • McGeary J (2009) The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: a review. Pharmacol Biochem Behav 93(3):222–229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mehroof M, Griffiths M (2010) Online gaming addiction: the role of sensation seeking, self-control, neuroticism, aggression, state anxiety, and trait anxiety. Cyberpsychol Behav Soc Netw 13(3):313–316

    Article  PubMed  Google Scholar 

  • Moran M, Blum K, Ponce JV, Lott L, Gondré-Lewis MC, Badgaiyan S et al (2021) High genetic addiction risk score (GARS) in chronically prescribed severe chronic opioid Probands attending multi-pain clinics: an open clinical pilot trial. Mol Neurobiol 58(7):3335–3346

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Noble EP (1998) The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes. Alcohol 16(1):33–45

    Article  CAS  PubMed  Google Scholar 

  • Noble EP (2003) D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B Neuropsychiatr Genet 116B(1):103–125

    Article  PubMed  Google Scholar 

  • Noble EP (2020) Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review. Eur Psychiatry 15(2):79–89

    Article  Google Scholar 

  • Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ (1991) Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48(7):648–654

    Article  CAS  PubMed  Google Scholar 

  • Noble EP, Blum K, Khalsa ME, Ritchie T, Montgomery A, Wood RC et al (1993) Allelic association of the D2 dopamine receptor gene with cocaine dependence. Drug Alcohol Depend 33(3):271–285

    Article  CAS  PubMed  Google Scholar 

  • Noble EP, Noble RE, Ritchie T, Syndulko K, Bohlman MC, Noble LA et al (1994) D2 dopamine receptor gene and obesity. Int J Eat Disord 15(3):205–217

    Article  CAS  PubMed  Google Scholar 

  • Nutt DJ, Lingford-Hughes A, Erritzoe D, Stokes PR (2015) The dopamine theory of addiction: 40 years of highs and lows. Nat Rev Neurosci 16(5):305–312

    Article  CAS  PubMed  Google Scholar 

  • Patriquin MA, Bauer IE, Soares JC, Graham DP, Nielsen DA (2015) Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. Psychiatr Genet 25(5):181–193

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Petry NM, Rehbein F, Gentile DA, Lemmens JS, Rumpf HJ, Mossle T et al (2014) An international consensus for assessing internet gaming disorder using the new DSM-5 approach. Addiction 109(9):1399–1406

    Article  PubMed  Google Scholar 

  • Potenza MN (2013) How central is dopamine to pathological gambling or gambling disorder? Front Behav Neurosci 7:206

    Article  PubMed  PubMed Central  Google Scholar 

  • Potenza MN (2018) Searching for replicable dopamine-related findings in gambling disorder. Biol Psychiatry 83(12):984–986

    Article  PubMed  Google Scholar 

  • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18(3):247–291

    Article  CAS  PubMed  Google Scholar 

  • Smith L, Watson M, Gates S, Ball D, Foxcroft D (2008) Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review. Am J Epidemiol 167(2):125–138

    Article  PubMed  Google Scholar 

  • Stautz K, Cooper A (2013) Impulsivity-related personality traits and adolescent alcohol use: a meta-analytic review. Clin Psychol Rev 33(4):574–592

    Article  PubMed  Google Scholar 

  • Taber KH, Black DN, Porrino LJ, Hurley RA (2012) Neuroanatomy of dopamine: reward and addiction. J Neuropsychiatry Clin Neurosci 24(1):1–4

    Article  PubMed  Google Scholar 

  • Tammimäki AE, Männistö PT (2010) Are genetic variants of COMT associated with addiction? Pharmacogenet Genomics 20(12)

    Google Scholar 

  • Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK et al (1997) D2 dopamine receptor gene (DRD2) Taq1 a polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 7(6):479–484

    Article  CAS  PubMed  Google Scholar 

  • Volkow ND, Wang G-J, Fowler JS, Tomasi D, Telang F (2011) Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci 108(37):15037–15042

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang F, Simen A, Arias A, Lu Q-W, Zhang H (2013) A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence. Hum Genet 132(3):347–358

    Article  CAS  PubMed  Google Scholar 

  • Weintraub D, Koester J, Potenza MN, Siderowf AD, Stacy M, Voon V et al (2010) Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Arch Neurol 67(5):589–595

    Article  PubMed  Google Scholar 

  • Wightman RM, Robinson DL (2002) Transient changes in mesolimbic dopamine and their association with ‘reward’. J Neurochem 82(4):721–735

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization (2018) International statistical classification of diseases and related health problems (11th Revision). 11th Revision. 2020, from https://icd.who.int/browse11/l-m/en

  • Yang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J (2008) Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Alcohol Clin Exp Res 32(12):2117–2127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Young RM, Lawford BR, Nutting A, Noble EP (2004) Advances in molecular genetics and the prevention and treatment of substance misuse: implications of association studies of the A1 allele of the D2 dopamine receptor gene. Addict Behav 29(7):1275–1294

    Article  PubMed  Google Scholar 

Download references

Funding:

This work was supported by the Hungarian National Research, Development and Innovation Office (Grant number: KKP126835). Eszter Kotyuk was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Science, BO/00099/21. Kenneth Blum was supported by R41MD012318/MD/NIMHD. Marc Potenza received support from the Connecticut Council on Problem Gambling. The views presented in this manuscript are those of the authors and the funding agencies did not have influence into the content of the manuscript beyond provision of financial support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zsolt Demetrovics .

Editor information

Editors and Affiliations

Appendix 1

Appendix 1

Reward Deficiency Syndrome Questionnaire (RDSQ-29) September 21, 2017

Below is a list of statements referring to everyday human behaviors. Simply indicate the extent to which each of the statements is true of yourself. There are no right or wrong answers.

 

Totally disagree

Somewhat disagree

Somewhat agree

Totally agree

1

I don’t receive gratification from everyday life.

1

2

3

4

2

While doing a task or work, I find myself already planning the next task.

1

2

3

4

3

I consistently seek new situations and adventures.

1

2

3

4

4

I like activities that’ll give me an adrenaline rush.

1

2

3

4

5

I prefer being active when going out with friends rather than just talking with each other.

1

2

3

4

6

I can never get enough sex.

1

2

3

4

7

I’m almost always active.

1

2

3

4

8

I desire to participate in all aspects of life no matter the limits.

1

2

3

4

9

I’ve tried many sports in my life.

1

2

3

4

10

Others would consider my activities dangerous.

1

2

3

4

11

I regularly change my sexual partners.

1

2

3

4

12

I like to be always active.

1

2

3

4

13

My friends and family often worry about my lifestyle.

1

2

3

4

14

I like experimenting with extreme sports.

1

2

3

4

15

I need more stimulation than others.

1

2

3

4

16

It can happen that I have more than one sexual partner at once.

1

2

3

4

17

I cannot stand inactivity.

1

2

3

4

18

My friends or my family warned me several times that I overdo my recreational activities.

1

2

3

4

19

Extreme sports stimulate me.

1

2

3

4

20

No pain or tiredness can deter me from doing something that I am passionate about.

1

2

3

4

21

If nothing special happens during the day, I feel empty and bored.

1

2

3

4

22

Most people think I can’t sit still.

1

2

3

4

23

I like to live dangerously.

1

2

3

4

24

I need more excitement than others.

1

2

3

4

25

I often want a good time no matter what I have to do to get it.

1

2

3

4

26

Being inactive really annoys me.

1

2

3

4

27

I look for extreme challenges in my work, sports, or anything else.

1

2

3

4

28

When I’m doing something pleasurable, I can hardly stop myself.

1

2

3

4

29

Often, I want to feel stimulated no matter what I have to do to get it.

1

2

3

4

  1. 1. Lack of sexual satisfaction (6, 11, 16)
  2. 2. Activity (2, 7, 17, 22, 26)
  3. 3. Social concerns (13, 18)
  4. 4. Risk-seeking behavior (9, 14, 19, 23, 27)
  5. 5. Additional items (1, 3, 4, 5, 8, 10, 12, 15, 20, 21, 24, 25, 28, 29)

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Kótyuk, E., Potenza, M.N., Blum, K., Demetrovics, Z. (2022). The Reward Deficiency Syndrome and Links with Addictive and Related Behaviors. In: Patel, V.B., Preedy, V.R. (eds) Handbook of Substance Misuse and Addictions. Springer, Cham. https://doi.org/10.1007/978-3-030-67928-6_3-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-67928-6_3-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-67928-6

  • Online ISBN: 978-3-030-67928-6

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics