Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Cholinesterases

  • Hermona SoreqEmail author
  • Erez Podoly
  • Muslum Gok
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_184-1
  • 13 Downloads

Synonyms

Definition

Cholinesterases (ChEs), polymorphic carboxylesterases of broad substrate specificity, terminate neurotransmission at cholinergic synapses and neuromuscular junctions (NMJs). Being sensitive to inhibition by organophosphate (OP) poisons, ChEs belong to the serine hydrolases (B type). ChEs share 65% amino acid sequence homology and have similar molecular forms and active center structures (Soreq and Seidman 2001). Substrate and inhibitor specificities classify ChEs into two subtypes:
  1. 1.

    Acetylcholinesterase (EC 3.1.1.7) (AChE)

    Primarily hydrolyses esters with short acyl moiety, such as...

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References

  1. Jasiecki J, Limon-Sztencel A, Żuk M, Chmara M, Cysewski D, Limon J, Wasąg B (2019) Synergy between the alteration in the N-terminal region of butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer’s disease. Sci Rep 9:5223CrossRefGoogle Scholar
  2. Silman I, Sussman JL (2005) Acetylcholinesterase: ‘classical’ and ‘nonclassical’ functions and pharmacology. Curr Opin Pharmacol 5:293–302CrossRefGoogle Scholar
  3. Simchovitz A, Heneka MT, Soreq H (2017) Personalized genetics of the cholinergic blockade of neuroinflammation. J Neurochem 142:178–187CrossRefGoogle Scholar
  4. Soreq H (2015) Checks and balances on cholinergic signaling in brain and body function. Trends Neurosci 38:448–458CrossRefGoogle Scholar
  5. Soreq H, Seidman S (2001) Acetylcholinesterase – new roles for an old actor. Nat Rev Neurosci 2:294CrossRefGoogle Scholar
  6. Taylor P (2011) Anticholinesterase agents. In: Goodman & Gilman’s the pharmacological basis of therapeutics, 12th edn. Macmillan, New York, pp 239–254Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Department of Biological Chemistry, The Life Sciences Institute and the Edmond and Lili Safra Center of Brain ScienceThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.Department of Medical BiochemistryHacettepe UniversityAnkaraTurkey