Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal


  • Hermona SoreqEmail author
  • Erez Podoly
  • Muslum Gok
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_184-1



Cholinesterases (ChEs), polymorphic carboxylesterases of broad substrate specificity, terminate neurotransmission at cholinergic synapses and neuromuscular junctions (NMJs). Being sensitive to inhibition by organophosphate (OP) poisons, ChEs belong to the serine hydrolases (B type). ChEs share 65% amino acid sequence homology and have similar molecular forms and active center structures (Soreq and Seidman 2001). Substrate and inhibitor specificities classify ChEs into two subtypes:
  1. 1.

    Acetylcholinesterase (EC (AChE)

    Primarily hydrolyses esters with short acyl moiety, such as...

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© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Department of Biological Chemistry, The Life Sciences Institute and the Edmond and Lili Safra Center of Brain ScienceThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.Department of Medical BiochemistryHacettepe UniversityAnkaraTurkey