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The ABC transporters represent one of the largest families of transmembrane proteins in most organisms including plants, bacteria, and eukaryotic cells. They perform numerous key physiological processes directly coupled with the hydrolysis of ATP. From the pharmacological point of view, ABC transporters are of special interest because of their relevance in transmembrane transport of various drugs, thereby modifying intracellular concentrations and hence effects of these compounds. Furthermore, they represent potential target structures to interfere with (patho-)physiological processes in which they are involved.
ATP-binding cassette (ABC) proteins are present in plants, bacteria, and eukaryotic organisms including mammalians. In humans the ABC gene superfamily comprises about 50 members, which are organized in 7 subfamilies called ABCA to ABCG on the basis of their domain organization and phylogenetic...
- Jansen RS, Kucukosmanoglu A, de Haas M, Sapthu S, Otero JA, Hegman IE, Bergen AA, Gorgels TG, Borst P, van de Wetering K (2013) ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci U S A 110:20206–20211CrossRefGoogle Scholar