Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Inflammasome

  • Tao Gong
  • Rongbin ZhouEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_10029-1
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Definition

Inflammasomes are cytoplasmic, multiprotein complexes that consist of a sensor molecule, the adaptor protein ASC, and the downstream protease pro-caspase-1. In response to microbial infection, environmental stimuli, or endogenous “danger signals,” several innate immune receptors, known as pattern recognition receptors (PRRs), can act as sensor molecules to initiate inflammasome assembly. Inflammasome assembly and activation lead to the autocatalytic cleavage of pro-caspase-1 into activated caspase-1. The activation of caspase-1 not only initiates the maturation and release of interleukins 1β (IL-1β) and IL-18 but also induces inflammatory cell death, termed “pyroptosis.”

Role of Inflammasomes in Infection and Diseases

The most well-described innate immune receptors initiating inflammasome assembly are NLRP1 (NLR family pyrin domain-containing 1), NLRP3, NLRP9b, NLRC4 (NLR family CARD domain-containing protein 4), IFI16 (interferon gamma-inducible protein 16), AIM2 (absent in...

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References

  1. Bertinaria M, Gastaldi S, Marini E, Giorgis M (2019) Development of covalent NLRP3 inflammasome inhibitors: chemistry and biological activity. Arch Biochem Biophys 670:116–139.  https://doi.org/10.1016/j.abb.2018.11.013CrossRefPubMedGoogle Scholar
  2. Gong T, Jiang W, Zhou R (2018a) Control of Inflammasome activation by phosphorylation. Trends Biochem Sci 43(9):685–699.  https://doi.org/10.1016/j.tibs.2018.06.008CrossRefPubMedGoogle Scholar
  3. Gong T, Yang Y, Jin T, Jiang W, Zhou R (2018b) Orchestration of NLRP3 inflammasome activation by ion fluxes. Trends Immunol 39(5):393–406.  https://doi.org/10.1016/j.it.2018.01.009CrossRefPubMedGoogle Scholar
  4. Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E (2018) Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov 17(8):588–606.  https://doi.org/10.1038/nrd.2018.97CrossRefPubMedGoogle Scholar
  5. Swanson KV, Deng M, Ting JPY (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19(8):477–489.  https://doi.org/10.1038/s41577-019-0165-0CrossRefPubMedGoogle Scholar

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.School of Basic Medical SciencesUniversity of Science and Technology of ChinaHefeiChina