Unified Principles of Thalamocortical Network Dynamics: A Framework for Typical/Atypical Functional Connectivity
In more recent years, there has been increased interest in understanding the brain’s functional connectivity within local and long-range networks. The structure and functional dynamics connectivity at the cortical level has received considerable attention, the structural and functional dynamics of thalamocortical interactions are as yet insufficiently integrated with our knowledge of large-scale connectivity and regional function. An important question, yet to be answered in detail, is how typical cognitive functions and their alterations in neuropsychiatric pathologies are temporally generated across the entire brain space (thalamocortical, corticocortical, corticothalamic) based on intact or altered brain structure, function, and neurochemistry.
We are reviewing MEG and related EEG research in the context of multimodal imaging findings, focusing on thalamocortical dynamics and their role in functional connectivity across corticocortical, and corticothalamic circuits, including oscillatory synchronization within and across the various frequency bands underlying cognition. We then further explore the cognitive consequences of various disruptions of thalamocortical and corticocortical dynamics, including slowing and selective loss of functional network dynamics in particular brain networks related to disabilities or neuropsychiatric pathologies.
We are presenting an overview of current findings and their conceptual implications for how brain imaging technologies can further contribute to a better understanding of the unified principles of the brain’s structural, functional, and temporal connectivity dynamics and their relationship to typical and atypical sensory-motor processing and cognition including consciousness.
KeywordsThalamocortical Corticocortical Corticothalamic Local and large-scale networks Thalamocortical processing Synchronization Functional connectivity dynamics Alpha Theta Gamma Unified principles Cognition Consciousness Cognitive deficit Neurology Psychiatry Traumatic brain injury
- Benasich AA, Fitch RH (2012) Developmental dyslexia. Paul H Brooks Publishing Co, BaltimoreGoogle Scholar
- Façon E, Steriade M, Wertheim N (1958) Hypersomnie prolongée engendrée par les lésions bilatérales du système activateur médial. Le syndrome thrombotique de la bifurcation du tronc basilaire. Rev Neurol (Paris) 98:117–133Google Scholar
- Fair DA, Bathula D, Mills KL, Costa Dias TG, Blythe MS, Zhang D et al.(2010) Maturing thalamocortical functional connectivity across development. Front Syst Neurosci 4:1–10Google Scholar
- Huang MX, Nichols S, Robb A, Angeles A, Drake A, Holland M, Asmussen S, D’Andrea J, Chun W, Levy M, Cui L, Song T, Baker DG, Hammer P, McLay R, Theilmann RJ, Coimbra R, Diwakar M, Boyd C, Neff J, Liu TT, Webb-Murphy J, Farinpour R, Cheung C, Harrington DL, Heister D, Lee RR (2012) An automatic MEG low-frequency source imaging approach for detecting injuries in mild and moderate TBI patients with blast and non-blast causes. NeuroImage 61:1067PubMedCrossRefPubMedCentralGoogle Scholar
- Ibrahim GM, Anderson RA, Akiyama T, Ochi A, Otsubo H, Singh-Cadieux G, Donner E, Rutka JT, Snead OC, Doesburg SM (2013) Neocortical pathological high-frequency oscillations are associated with frequency-dependent alterations in functional network topology. J Neurophysiol 110(10):2475–2483PubMedCrossRefPubMedCentralGoogle Scholar
- Ibrahim GM, Wong SM, Anderson RA, Singh-Cadieux G, Akiyama T, Ochi A, Otsubo H, Okanishi T, Vailiante TA, Donner E, Rutka JT, Snead OC, Doesburg SM (2014) Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms. Exp Neurol 251:30–38PubMedCrossRefPubMedCentralGoogle Scholar
- Jeanmonod D, Magnin M, Morel A, Siegemund M, Cancro R, Lanz M, Llinás R, Ribary U, Kronberg E, Schulman JJ, Zonenshayn M (2001) Thalamocortical dysrhythmia II: clinical and surgical aspects. Thalamus Relat Syst 1:245–254Google Scholar
- Jones EG (2009) Synchrony in the interconnected circuitry of the thalamus and cerebral cortex. In: Schiff ND, Laureys S (eds) Disorders of consciousness, Annals of the New York Academy of Sciences (En ligne), vol 1157. New York Academy of Sciences, Boston, pp 10–23Google Scholar
- Laureys S, Gosseries O, Tononi G (2015) The neurology of consciousness: cognitive neuroscience and neuropathology. Academic, San DiegoGoogle Scholar
- Llinás R, Ribary U, Tallal P (1998a) Dyschronic language-based learning disability. In: Von Euler C, Lundberg I, Llinás R (eds) Basic mechanisms in cognition and language. Elsevier Science, New York, pp 101–108Google Scholar
- Ribary U, Joliot M, Miller SL, Kronberg E, Cappell J, Tallal P, Llinás R (2000) Cognitive temporal binding and its relation to 40Hz activity in humans: alteration during dyslexia. In: Aine C, Okada Y, Stroink G, Swithenby S, Wood CC (eds) Biomag96. Springer, Berlin, pp 971–974Google Scholar
- Ribary U, Doesburg SM, Ward LM (2014) Thalamocortical network dynamics: a framework for typical/atypical cortical oscillations and connectivity. In: Supek S, Aine CJ (eds) Magnetoencephalography – from signals to dynamic cortical networks. Springer, Heidelberg, pp 429–450Google Scholar
- Ribary U, Mackay AL, Rauscher A, Tipper CM, Giaschi D, Woodward TS, Sossi V, Doesburg SM, Ward LM, Herdman A, Hamarneh G, Booth BG, Moiseev A (2017b) Emerging neuroimaging technologies: towards future personalized diagnostics, prognosis, targeted intervention and ethical challenges. In: Illes J, Hossain S (eds) Neuroethics: anticipating the future. Oxford University Press, Oxford, pp 15–53Google Scholar
- Sherman SM, Guillery RW (2006) Exploring the thalamus and its role in cortical function. MIT Press, Cambridge, MAGoogle Scholar