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Generalized Epilepsy with Febrile Seizures Plus (GEFS+)

  • Douglas R. NordliJr.
Reference work entry

Brief History/Evolution of the Concept

Generalized (or genetic) epilepsy with febrile seizures plus is often abbreviated as GEFS+. Scheffer and colleagues regard it as a familial epilepsy syndrome and first described it in 1997. Their observations were based upon a very careful and extensive examination of large families with multiple affected individuals (Scheffer and Berkovic 1997). Family members had febrile seizures (FS) alone, febrile seizures plus (FS+), or afebrile seizures. FS+ was used to describe individuals who had some atypical feature to their FS such as a presentation before 3 months or after 6 years of age. Also, FS+ could refer to the presence of afebrile seizures. Initially, the afebrile seizures in these individuals were noted to be generalized, including absence, convulsions, and myoclonus and atonic seizures. In fact, generalized seizures are still the predominant afebrile generalized seizures in these families; however, temporal lobe epilepsy has also been...

Keywords

Temporal Lobe Epilepsy Febrile Seizure Focal Seizure Infantile Spasm Focal Epilepsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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  2. Audenaert D, Claes L et al. (2003) A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy. Neurology 61(6): 854–856PubMedGoogle Scholar
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  7. Scheffer IE, Berkovic SF (1997) Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain 120(Pt 3):479–490CrossRefPubMedGoogle Scholar
  8. Singh R, Scheffer IE et al. (1999) Generalized epilepsy with febrile seizures plus: a common childhood-onset genetic epilepsy syndrome. Ann Neurol 45(1):75–81CrossRefPubMedGoogle Scholar
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Copyright information

© Springer-Verlag London Limited 2010

Authors and Affiliations

  • Douglas R. NordliJr.
    • 1
  1. 1.Lorna S. and James P. Langdon Chair of Pediatric Epileps, Children’s Memorial HospitalChicagoUSA

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