Mucosal Immunity to HIV-1
Mucosal immunity refers to innate and adaptive immune responses that defend mucosal surfaces, which are the surfaces of the body that line passageways exposed to the external environment, such as the respiratory, gastrointestinal, and reproductive tracts. These defenses protect the body against potentially pathogenic microbes, including HIV-1. This review focuses on immune defenses in the female reproductive tract, the male reproductive tract, and the gastrointestinal tract, which are the major portals of entry for HIV-1.
Female Reproductive Tract
FRT and HIV-1 transmission (HIV-1 Sexual Transmission, Overview). Women (Women, Epidemiology of HIV/AIDS) account for approximately half of the 34 million individuals with HIV-1; nevertheless, transmission via the female reproductive tract (FRT) (Identifying Opportunities to Block HIV-1 Transmission in the Female Genital Tract) is relatively inefficient, with an estimated relative probability of 1 transmission per 200–2,000...
KeywordsSexually Transmitted Infection Simian Immunodeficiency Virus Male Circumcision Female Reproductive Tract Secretory Leukocyte Protease Inhibitor
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