Encyclopedia of Medical Immunology

Living Edition
| Editors: Ian MacKay, Noel R. Rose

Mammalian Sterile 20-Like 1 (MST1) Deficiency

  • Robert P. NelsonJr.Email author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-9209-2_107-1

MST1/STK4 (OMIM: #614868)

Synonyms

Introduction/Background

Mammalian sterile 20-like 1 kinase (MST1, official gene name serine/threonine kinase 4, STK4), a member of the “sterile 20” family of proteins, is a cytosolic kinase that participates in a broad array of biological processes affecting immune function and hematopoiesis. It is activated upstream of other mitogen-activated kinases, in response to stress. The gene encoding MST1/STK4 is mapped to chromosome 20q13.12. As a major component of the Hippo pathway, MST1/STK4 regulates apoptosis and plays an important role in the cellular response to oxidative stress. Given that the Hippo pathway is key to the regulation of cell proliferation and survival, MST1/STK4 is a link in the signaling pathway that contributes to governing the self-renewal and differentiation of stem and progenitor cells (Torres-Bacete et al. 2015).

Consistent with the majority of T- and B-cell combined immunodeficiencies, MST1 is...

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References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Divisions of Hematology and Oncology, Stem Cell Transplant ProgramIndiana University (IU) School of Medicine and the IU Bren and Simon Cancer CenterIndianapolisUSA
  2. 2.Pediatric Immunodeficiency ClinicRiley Hospital for Children at Indiana University HealthIndianapolisUSA
  3. 3.Professor of Medicine and PediatricsIndiana University School of Medicine, Immunohematology and TransplantationIndianapolisUSA

Section editors and affiliations

  • M Teresa de la Morena
    • 1
  • Robert P. NelsonJr.
    • 2
  1. 1.University of Washington and Seattle Children’s HospitalSeattleUSA
  2. 2.Hematology and OncologyIndiana UniversityIndianapolisUSA