A gene that encodes a protein that augments BCL10-induced activation of NF-kappa B.
In the 1980s, Isaacson et al. suggested that histochemical and genetic similarities exist between Mediterranean lymphoma and primary gastrointestinal lymphoma of follicle center cell origin. These include a dense, noninvasive monotypic lamina propria plasma cell infiltrate, individual gland invasion, clonality, and a common histogenesis from mucosa-associated lymphoid-tissue (MALT) (Isaacson and Wright 1983; Diebold 1988; Horsman et al. 1992). The MALT1gene product is a caspase-like (paracaspase) cysteine protease that participates in the signal transduction cascade triggered by the formation of immunoreceptor/peptide-MHC complexes at T and B cell surfaces. Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1) mediates T and B cell receptor-induced NF-kappa B...
- Wiegmann H, Reunert J, Metze D, et al. Refining the dermatological spectrum in primary immunodeficiency: MALT1 deficiency mimicking Netherton- and Omenn syndrome. Br J Dermatol. 2019; https://doi.org/10.1111/bjd.18091.