Encyclopedia of Malaria

Living Edition
| Editors: Peter G. Kremsner, Sanjeev Krishna

1-Deoxy-d-Xylulose 5-Phosphate Pathway

  • Jochen Wiesner
  • Hassan Jomaa
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-8757-9_10-1

Synonyms

Definition

The 1-deoxy- d-xylulose 5-phosphate (DXP) pathway is a metabolic pathway for the conversion of pyruvate and d-glyceraldehyde 3-phosphate (G3P) into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) by seven enzymatic reaction steps (all intermediates and enzymes together with their common abbreviations are listed in Tables 1 and 2, respectively). In all organisms studied so far, IPP and DMAPP are the precursor molecules for the synthesis of a class of biomolecules known as isoprenoids (or terpenoids). In P. falciparum, the DXP pathway is the only metabolic route leading to IPP and DMAPP. The enzymes of the DXP pathway of P. falciparum are localized inside the apicoplast. The DXP pathway is absent in humans who use the well-known mevalonate pathway instead (Fig. 1). Through the mevalonate pathway, three molecules of acetyl CoA...

Keywords

Antimalarial Activity Mevalonate Pathway Parasite Growth Dimethylallyl Diphosphate Isoprenoid Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Bioresources Project GroupFraunhofer Institute for Molecular Biology and Applied Ecology IMEGießenGermany
  2. 2.Institute for Clinical Immunology and Transfusion MedicineJustus-Liebig University GießenGießenGermany