Encyclopedia of Database Systems

2018 Edition
| Editors: Ling Liu, M. Tamer Özsu

Gene Expression Arrays

  • Mehmet M. Dalkiliç
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-8265-9_1435

Definition

A gene expression array (or DNA microarray) is a miniature, massively parallel, and semi-automated process that measures levels of gene products (or mRNA or transcripts). The DNA of an organism (cell or cells) is a set of instructions used to direct its existence. A genetic message is transcribed from DNA into mRNA (messenger RNA), then typically translated into protein. By measuring the levels of mRNA, an indirect glimpse can be taken into the functioning of a cell. The relative and absolute levels of the transcripts are called expressions, and this instantaneous set of expressions is called the expression profile. Profiles can be used, for example, to indicate a disease state.

Historical Background

DNA and RNA are bio-molecules that hybridizebonding due to complementary structure. Hybridization has been used for several decades as means of identifying DNA and RNA present in an organism (cell or cells). Until microarray technology was invented, utilizing hybridization was...

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Recommended Reading

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Indiana UniversityBloomingtonUSA

Section editors and affiliations

  • Louiqa Raschid
    • 1
  1. 1.Robert H. Smith School of BusinessUniversity of MarylandCollege ParkUSA