Reference Work Entry

Diet and Nutrition in Critical Care

pp 1729-1732


Enteral Diets and Parenteral Feedings with Different n-6/n-3 Ratios in Rats and Mice

  • Nakamichi WatanabeAffiliated withDepartment of Food Science and Nutrition, Showa Women’s University Email author 


This chapter discusses animal studies in rats. N-3 polyunsaturated fatty acids (PUFAs) have been shown to suppress inflammation and regulate the immune response. These effects were reported with enteral diets administered during heart allotransplantation, sepsis, and intestinal damage. Additionally, n-3 PUFAs improve blood flow in the intestine. Moreover, animal studies reveal the importance of n-6/n-3 ratios of enteral diets in both short-term and long-term administration due to the influence on n-6/n-3 ratios in some tissues including the brain.