Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

SenseLab: Integration of Multidisciplinary Neuroscience Data

  • Gordon M. ShepherdEmail author
  • Thomas M. Morse
  • Luis Marenco
  • Kei Cheung
  • Ted Carnevale
  • Michele Migliore
  • Robert A. McDougal
  • Michael Hines
  • Perry Miller
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_497-1

Definition

The SenseLab project involves novel informatics approaches to constructing databases and Web-enabled applications for collecting, modeling, analyzing, and sharing neuroscience information. The emphasis of SenseLab (http://www.senselab.org) is on building experimental data into integrated, multidisciplinary models of neurons and neural systems in order to gain insight into the neural basis of behavior. SenseLab is also part of the Neuroscience Information Framework (NIF) project and the International Neuroinformatics Coordinating Facility (INCF).

Detailed Description

SenseLab was founded in 1993 as part of the original Human Brain Project sponsored by the National Institutes of Health, National Science Foundation, and several other government funding agencies in the United States, which began the development of neuroinformatics tools in support of neuroscience research. Using the olfactory system as a model, SenseLab has built a suite of nine databases (see Fig. 1) to...

Keywords

Olfactory Bulb Olfactory Receptor Synaptic Organization Olfactory Glomerulus Neuroscience Information Framework 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Notes

Acknowledgments

We gratefully acknowledge funding from NIH grant DC009977.

References

  1. Buck L, Axel R (1991) A novel multigene family may encode odorant receptors – a molecular-basis for odor recognition. Cell 65:175–187PubMedCrossRefGoogle Scholar
  2. Hines ML, Carnevale NT (2014) NEURON Simulation Environment. In: Kotaleski JH, Crook S, (eds) Encyclopedia of computational neuroscience, SpringerGoogle Scholar
  3. Migliore M, Cavarretta F, Hines ML, Shepherd GM (2013) Functional neurology of a brain system: a 3D olfactory bulb model to process natural odorants. Funct Neurol 2013 28(3):241–243PubMedCentralPubMedGoogle Scholar
  4. Pechura CM, Martin JB (1991) Mapping the brain and its functions: integrating enabling technologies into neuroscience research. National Academy Press, Washington, DCGoogle Scholar
  5. Rall W, Shepherd GM (1968) Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. J neurophysiol 31:884–915PubMedGoogle Scholar
  6. Shepherd GM (2004) The synaptic organization of the brain, 5th edn. Oxford University Press, OxfordCrossRefGoogle Scholar
  7. Shepherd GM, Grillner S (2010) Handbook of brain microcircuits. Oxford University Press, New YorkCrossRefGoogle Scholar
  8. Yu Y, McTavish TS, Hines ML, Shepherd GM, Valenti C, Migliore M (2013) Sparse distributed representation of odors in a large-scale olfactory bulb circuit. PLoS Comput Biol 9:e1003014PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Gordon M. Shepherd
    • 1
    Email author
  • Thomas M. Morse
    • 1
  • Luis Marenco
    • 2
    • 4
  • Kei Cheung
    • 2
    • 4
  • Ted Carnevale
    • 1
  • Michele Migliore
    • 1
    • 5
  • Robert A. McDougal
    • 1
  • Michael Hines
    • 3
  • Perry Miller
    • 2
    • 4
  1. 1.Department of NeurobiologyYale University School of MedicineNew HavenUSA
  2. 2.Center for Medical InformaticsYale University School of MedicineNew HavenUSA
  3. 3.Department of NeurobiologyYale UniversityNew HavenUSA
  4. 4.VA Connecticut Healthcare SystemWest HavenUSA
  5. 5.Institute of Biophysics National Research CouncilPalermoItlay