Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Drosophila Connectome

  • Arjun BhariokeEmail author
  • Louis K. Scheffer
  • Dmitri B. Chklovskii
  • Ian A. Meinertzhagen
Living reference work entry

Later version available View entry history

DOI: https://doi.org/10.1007/978-1-4614-7320-6_275-1


The Drosophila connectome is a comprehensive description of all the connections between subunits comprising the central nervous system (CNS) of the fruit fly, Drosophila melanogaster.

The CNS of Drosophila consists of the brain and ventral ganglion. It has a volume of ~0.07 mm 3 (see Rein et al. 2002, Table 1). To compare, this is similar to the volume of a single cortical column in mouse barrel cortex (~0.09 mm 3) (Lefort et al. 2009; Hooks et al. 2011). The Drosophila brain can be subdivided into smaller neuropil compartments (Fig. 1), identified through anatomical boundaries (Ito et al. 2014), as well as the overlapping arborizations of the neurons constituting each neuropil compartment (Chiang et al. 2011; Jenett et al. 2012). In total, across these compartments, the Drosophilabrain is thought to contain ~90,000 cells, of which ~90 % are neurons. These neurons can be classified into discrete cell types, with stereotypical shapes and synaptic connections, using both human...


Synaptic Contact Antennal Lobe Optic Lobe Reporter Line Drosophila Brain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Borst A, Haag J, Reiff DF (2010) Fly motion vision. Annu Rev Neurosci 33:49–70PubMedCrossRefGoogle Scholar
  2. Caron SJ, Ruta V, Abbott L, Axel R (2013) Random convergence of olfactory inputs in the Drosophila mushroom body. Nature 497:113–117Google Scholar
  3. Chiang AS et al (2011) Three‐dimensional reconstruction of brain‐wide wiring networks in Drosophila at single‐cell resolution. Curr Biol 21:1–11PubMedCrossRefGoogle Scholar
  4. Chou Y-H et al (2010) Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe. Nat Neurosci 13:439–449PubMedCentralPubMedCrossRefGoogle Scholar
  5. Franceschini N, Kirschfeld K, Minke B (1981) Fluorescence of photoreceptor cells observed in vivo. Science 213:1264–1267PubMedCrossRefGoogle Scholar
  6. Gao S et al (2008) The neural substrate of spectral preference in Drosophila. Neuron 60:328–342PubMedCentralPubMedCrossRefGoogle Scholar
  7. Heisenberg M, Wolf R (1984) Vision in Drosophila. Genetics of microbehaviour. SpringerCrossRefGoogle Scholar
  8. Hooks B et al (2011) Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas. PLoS Biol 9:e1000572PubMedCentralPubMedCrossRefGoogle Scholar
  9. Ito K, Shinomiya K, Ito M et al (2014) A systematic nomenclature for the insect brain. Neuron (in press)Google Scholar
  10. Ito M, Masuda N, Shinomiya K, Endo K, Ito K (2013) Systematic analysis of neural projections reveals clonal composition of the Drosophila brain. Curr Biol 23:644–655Google Scholar
  11. Jenett A et al (2012) A GAL4‐driver line resource for Drosophila neurobiology. Cell Rep 2:991–1001Google Scholar
  12. Large VRML model with brain strutures labeled. Flybrain on‐line: http://www.flybrain.org. Accession number: AB00122
  13. Lefort S, Tomm C, Floyd Sarria J-C, Petersen CC (2009) The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. Neuron 61:301–316Google Scholar
  14. Meinertzhagen IA, Lee C-H (2011) The genetic analysis of functional connectomics in Drosophila. Adv Genet 80:99–151CrossRefGoogle Scholar
  15. Meinertzhagen I, O’neil S (1991) Synaptic organization of columnar elements in the lamina of the wild type in Drosophila melanogaster. J Comp Neurol 305:232–263PubMedCrossRefGoogle Scholar
  16. Murthy M, Fiete I, Laurent G (2008) Testing odor response stereotypy in the Drosophila mushroom body. Neuron 59:1009–1023PubMedCentralPubMedCrossRefGoogle Scholar
  17. Rein K, Zöckler M, Mader MT, Grübel C, Heisenberg M (2002) The Drosophila standard brain. Curr Biol 12:227–231PubMedCrossRefGoogle Scholar
  18. Rivera‐Alba M et al (2011) Wiring economy and volume exclusion determine neuronal placement in the Drosophila brain. Curr Biol 21:2000–2005PubMedCentralPubMedCrossRefGoogle Scholar
  19. Takemura SY et al (2013) A visual motion detection circuit suggested by Drosophila connectomics. Nature 500:175–181PubMedCentralPubMedCrossRefGoogle Scholar
  20. Tuthill JC, Nern A, Holtz SL, Rubin GM, Reiser MB (2013) Contributions of the 12 neuron classes in the fly lamina to motion vision. Neuron 79:128–140PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Arjun Bharioke
    • 1
    Email author
  • Louis K. Scheffer
    • 1
  • Dmitri B. Chklovskii
    • 1
  • Ian A. Meinertzhagen
    • 2
  1. 1.Janelia Farm Research CampusHoward Hughes Medical InstituteAshburnUSA
  2. 2.Department of Psychology and NeuroscienceDalhousie UniversityHalifaxCanada