Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Peripheral Nerve Interface, Regenerative

  • Mario Romero-Ortega
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_212-1


Regenerative peripheral interfaces (RPIs) are implantable devices that rely on the spontaneous regenerative capability of the injured peripheral nervous system to establish a bidirectional flow of information between the transected nerves in amputees and smart robotic prosthetics. RPIs are designed to provide intuitive movement and natural feel to advanced prosthetics for amputees and are characterized by the placement of multielectrode arrays (MEAs) in the regenerative path of their transected peripheral nerves. The MEAs detect motor commands from the brain as extracellular action potentials (AP) in the microvolt range traveling down their amputated nerves and use them to control the robotic prosthetic limb. In addition, RPIs can translate information from sensors populating the robotic limb to the user, by electrically stimulating axons in the nerve that elongate from neurons in the dorsal root ganglia.

Detailed Description

Regenerative Peripheral Interfaces (RPIs)



Transect Nerve Microelectrode Array Awake Animal Nerve Conduit Regenerative Path 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of BioengineeringThe University of Texas at DallasRichardsonUSA