Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Calcium Waves

  • M. Saleet JafriEmail author
  • Aman Ullah
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_182-1

Definition

A calcium wave is a transient rise in cytosolic calcium concentration that propagates spatially within the cell. It has the property that it is regenerative and is followed by a refractory period. It is believed that the wave carries a signal from one part of the cell to another.

Detailed Description

Calcium ions play an important role in a variety of cellular functions that impact nearly all aspects of cellular life. In fact, the calcium signal is one of the most versatile and universal signaling agents of the human body that controls almost everything we do – Ca2+ ions contribute to egg activation upon fertilization, muscle contraction, enzyme secretion, neurotransmitter release, how our brains process information and store memories, wound healing, and apoptosis. Calcium ions play such an important role in so many biological processes that it has been branded as the “life and death signal” (Berridge et al. 1998).

At rest, intracellular calcium concentration remains low,...

Keywords

Calcium Release Endoplasmic Reticulum Membrane Calcium Wave Kinematic Wave Cytosolic Calcium Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.School of Systems Biology and Krasnow Institute for Advanced StudiesGeorge Mason UniversityFairfaxUSA