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Biophysical Models of Calcium-Dependent Exocytosis

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Synonyms

Non-constitutive exocytosis; Regulated exocytosis

Definition

Calcium-dependent exocytosis is the biochemically controlled fusion of the bilipid secretory vesicle membrane with the bilipid cell membrane, triggered by the binding of several calcium ions (Ca2+) to control proteins such as synaptotagmins anchored at the interface between these two membranes. Exocytosis results in the release of vesicle contents into the extracellular space, namely the release of neurotransmitter into the synaptic cleft in the case of neuronal synapses and neuromuscular junctions, or the secretion of hormone into the blood stream in the case of endocrine cells. Exocytosis also allows the transmembrane proteins contained in the vesicle membrane to be incorporated into the cell membrane, although such membrane protein trafficking is more characteristic of Ca2+-independent, constitutive exocytosis.

Detailed Description

In synapses, neuromuscular junctions, and endocrine cells, exocytosis of a...

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Acknowledgments

This work was supported in part by NSF grant DMS-1517085

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  1. Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ, USA

    Victor Matveev

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    Ranu Jung

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    Kim T. Blackwell

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Matveev, V. (2020). Biophysical Models of Calcium-Dependent Exocytosis. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_178-2

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    Biophysical Models of Calcium-Dependent Exocytosis
    Published:
    17 January 2020

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_178-2

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    Calcium-Dependent Exocytosis, Biophysical Models of
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    05 April 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_178-1

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