Dynamic Clamp Technique
- Thomas NowotnyAffiliated withCentre for Computational Neuroscience and Robotics, School of Engineering and Informatics, University of Sussex Email author
- , Pablo VaronaAffiliated withDepartamento de Ingenieria Informatica, Universidad Autónoma de Madrid
Dynamic clamp is an electrophysiological technique for introducing simulated electrical components into biological cells using a real-time closed loop between the cell and a computer or another electronic device. Classic dynamic clamp protocols build a voltage-dependent current injection cycle to implement artificial membrane or synaptic conductances in the cell membrane of biological neurons. These protocols are employed to assess a large variety of neuronal computational properties and are widely applied for studying the physiology of neural systems at the cellular and circuit levels.
The use of closed-loop feedback interactions with living neurons for observation and control purposes goes back to the beginnings of electrophysiology when the voltage clamp technique was developed (Marmont 1949; Cole 1955). The voltage clamp technique measures currents across the membrane of excitable cells while holding the membrane potential at a constant level. In ...
Reference Work Entry Metrics
Date: 2014 (Latest)History
- 2014 (Latest)
- Dynamic Clamp Technique
- Reference Work Title
- Encyclopedia of Computational Neuroscience
- pp 1-4
- Online ISBN
- Springer New York
- Copyright Holder
- Springer Science+Business Media New York
- Industry Sectors
- eBook Packages
- Editor Affiliations
- 2. Department of Biomedical Engineering, Florida International University
- Author Affiliations
- 3. Centre for Computational Neuroscience and Robotics, School of Engineering and Informatics, University of Sussex, BN1 9QJ, Falmer, Brighton, UK
- 4. Departamento de Ingenieria Informatica, Universidad Autónoma de Madrid, 28049, Madrid, Spain
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