Action Potential Back-Propagation
Action potential (AP) back-propagation, as opposed to forward-propagation along the axon, consists of the conduction of the axonally initiated AP along neuronal dendrites, in the form of a depolarization sustained by both active and passive mechanisms. The amplitude of the depolarization generally decreases along the dendrites with increasing distance from the soma; the degree of attenuation is highly variable and depends on the neuronal type.
This work was supported by the National Institutes of Health (grant NIH R01 MH115832 under the CRCNS program to SG) and by the Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) to MM.