Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Action Potential Back-Propagation

  • Sonia GaspariniEmail author
  • Michele Migliore
Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-1-4614-7320-6_123-5



Action potential (AP) back-propagation, as opposed to forward-propagation along the axon, consists of the conduction of the axonally initiated AP along neuronal dendrites, in the form of a depolarization sustained by both active and passive mechanisms. The amplitude of the depolarization generally decreases along the dendrites with increasing distance from the soma; the degree of attenuation is highly variable and depends on the neuronal type.

Detailed Description

Simultaneous recordings from dendrites, soma, and axon have shown that action potentials are generally initiated in the axon initial segment, the region with the lowest threshold for AP initiation (Stuart et al. 1997; Spruston et al. 2016). In addition to canonical forward-propagation along the axon to the presynaptic terminals, APs rapidly invade the soma and propagate back into the dendrites, where voltage-dependent channels actively...
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This work was supported by the National Institutes of Health (grant NIH R01 MH115832 under the CRCNS program to SG) and by the Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) to MM.


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Further Reading

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Neuroscience CenterLouisiana State University Health Sciences Center-New OrleansNew OrleansUSA
  2. 2.National Research CouncilInstitute of BiophysicsPalermoItaly

Section editors and affiliations

  • Volker Steuber
    • 1
  1. 1.Centre for Computer Science and Informatics ResearchUniversity of HertfordshireHatfieldUK