Skip to main content

Intracellular Calcium Signals in Astrocytes, Computational Modeling of

  • Living reference work entry
  • First Online:
Book cover Encyclopedia of Computational Neuroscience

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Bindocci E, Savtchouk I, Liaudet N, Becker D, Carriero G, Volterra A (2017) Three-dimensional Ca2+ imaging advances understanding of astrocyte biology. Science 356:eaai8185

    Article  Google Scholar 

  • Brazhe AR, Postnov DE, Sosnovtseva O (2018) Astrocyte calcium signaling: interplay between structural and dynamical patterns. Chaos Interdisciplinary J Nonlinear Sci 28:106320

    Article  CAS  Google Scholar 

  • Burrage K, Burrage PM, Leier A, Marquez-Lago T, Nicolau DV (2011) Stochastic Simulation for Spatial Modelling of Dynamic Processes in a Living Cell. In: Koeppl H, Setti G, di Bernardo M, Densmore D (eds) Design and Analysis of Biomolecular Circuits: Engineering Approaches to Systems and Synthetic Biology. Springer, New York, pp 43–62

    Chapter  Google Scholar 

  • Calì C, Baghabra J, Boges DJ, Holst GR, Kreshuk A, Hamprecht FA, Srinivasan M, Lehvslaiho H, Magistretti PJ (2016) Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues. J Comp Neurol 524:23–38

    Article  Google Scholar 

  • Cresswel-Clay E, Crock N, Tabak J, Erlebacher G (2018) A compartmental model to investigate local and global Ca2+ dynamics in astrocytes. Front Comput Neurosci 12:94

    Article  Google Scholar 

  • De Pittà M, Ben-Jacob E, Berry H (2019) G protein-coupled receptor-mediated calcium signaling in astrocytes. In: De Pittà M, Berry H (eds) Computational Glioscience. Springer series in computational neuroscience. Springer International Publishing, Cham, pp 115–150

    Google Scholar 

  • Denizot MA, Nägerl UV, Soula H, Berry H (2019) Simulation of calcium signaling in fine astrocytic processes: effect of spatial properties on spontaneous activity. PLOS Computational Biology 15:e1006795

    Article  CAS  Google Scholar 

  • Dupont G, Falcke M, Kirk V, Sneyd J (2016) Basic modelling principles: deterministic models. In: Dupont G, Falcke M, Kirk V, Sneyd J (eds) Models of Calcium Signalling. Interdisciplinary Applied Mathematics. Springer International Publishing, Cham, pp 97–161

    Chapter  Google Scholar 

  • Giaume C, Venance L (1998) Intercellular calcium signaling and gap junctional communication in astrocytes. Glia 24:50–64

    Article  CAS  Google Scholar 

  • Kanemaru K, Sekiya H, Xu M, Satoh K, Kitajima N, Yoshida K, Okubo Y, Sasaki T, Moritoh S, Hasuwa H, Mimura M, Horikawa K, Matsui K, Nagai T, Iino M, Tanaka K (2014) In Vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca2+ Indicator. Cell Rep 8:311–318

    Article  CAS  Google Scholar 

  • Lavrentovich M, Hemkin S (2008) A mathematical model of spontaneous calcium(II) oscillations in astrocytes. J Theor Biol 251:553–560

    Article  CAS  Google Scholar 

  • Manninen T, Havela R, Linne M-L (2018) Computational models for calcium-mediated astrocyte functions. Front Comput Neurosci 12:14

    Article  Google Scholar 

  • Rüdiger S, Shuai J (2019) Modeling of stochastic Ca2+ signals. In: De Pittà M, Berry H (eds) Computational Glioscience. Springer series in computational neuroscience. Springer International Publishing, Cham, pp 91–114

    Google Scholar 

  • Rizzuto R, Pozzan T (2006) Microdomains of intracellular Ca2+: molecular determinants and functional consequences. Physiol Rev 86:369–408

    Article  CAS  Google Scholar 

  • Rohlmann A, Wolff JR (1996) Subcellular topography and plasticity of gap junction distribution on astrocytes. Springer Link, pp. 175–192

    Google Scholar 

  • Savtchenko LP, Bard L, Jensen TP, Reynolds JP, Kraev I, Medvedev N, Stewart MG, Henneberger C, Rusakov DA (2018) Disentangling astroglial physiology with a realistic cell model in silico. Nat Commun 9(1):3554

    Article  Google Scholar 

  • Savtchouk I, Volterra A (2018) Gliotransmission: beyond black-and-white. J Neurosci 38:14–25

    Article  CAS  Google Scholar 

  • Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH, Khakh BS (2013) Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J Gen Physiol 141:633–647

    Article  CAS  Google Scholar 

  • Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P, Khakh BS (2015) Ca(2+) signaling in astrocytes from Ip3r2(−/−) mice in brain slices and during startle responses in vivo. Nat Neurosci 18:708–717

    Article  CAS  Google Scholar 

  • Verkhratsky A, Nedergaard M (2018) Physiology of Astroglia. Physiol Rev 98:239–389

    Article  CAS  Google Scholar 

  • Winkelmann S, Schütt C (2017) Hybrid models for chemical reaction networks: multiscale theory and application to gene regulatory systems. J Chem Phys 147:114115

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sharmila Venugopal .

Editor information

Editors and Affiliations

Section Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Science+Business Media, LLC, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Denizot, A., Berry, H., Venugopal, S. (2020). Intracellular Calcium Signals in Astrocytes, Computational Modeling of. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_100693-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_100693-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7320-6

  • Online ISBN: 978-1-4614-7320-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics