Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Intracellular Calcium Signals in Astrocytes, Computational Modeling of

  • Audrey Denizot
  • Hugues Berry
  • Sharmila VenugopalEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_100693-1
  • 15 Downloads

Definition

Astrocytes are a predominant type of glia in the central nervous system. Although they do not generate electrical signals like neurons, they display a form of excitability characterized by fluctuations in their intracellular Ca2+ levels. These Ca2+ fluctuations show remarkable spatiotemporal complexity and diversity and further respond to various cellular stimuli. Modeling astrocyte Ca2+ dynamics is an essential step toward understanding their physiology and functions within neural circuits. This entry highlights the computational methods and approaches for modeling intracellular Ca2+ signals in astrocytes at the single cell level.

Detailed Description

Astrocytes are ubiquitously distributed throughout the central nervous system. Each astrocyte can display a complex morphology characterized by distinct compartments: the soma, primary branches and numerous fine processes, also referred to as branchlets. The latter account for around 75% of the surface of the astrocytic plasma...
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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Audrey Denizot
    • 1
    • 2
  • Hugues Berry
    • 1
    • 2
  • Sharmila Venugopal
    • 3
    Email author
  1. 1.INRIAVilleurbanneFrance
  2. 2.LIRIS, UMR5205 CNRS, F-69621University of LyonVilleurbanneFrance
  3. 3.Department of Integrative Biology and PhysiologyUniversity of California Los AngelesLos AngelesUSA

Section editors and affiliations

  • Sharmila Venugopal
    • 1
  • Rahul Srinivasan
    • 2
  1. 1.Department of Integrative Biology and PhysiologyUniversity of California Los AngelesLos AngelesUSA
  2. 2.Department of Neuroscience and Experimental TherapeuticsTexas A&M Health Science CenterBryanUSA