Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Biomechanical Modeling of Traumatic Brain Injury

  • Songbai Ji
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_100668-1



finite element


grey matter


traumatic brain injury


white matter


Biomechanical modeling of traumatic brain injury (TBI) refers to the use of a computer model of the human head to simulate brain mechanical responses when the head is subjected to external blunt impact or blast exposure. The resulting tissue responses such as strain, strain rate, and pressure in specific regions of the brain can then be used to predict the occurrence of TBI.

Detailed Description

A computational head injury model is composed of three basic constituents: model geometry, boundary conditions, and tissue material properties. With properly measured impact loading conditions as input for simulation, whole-brain biomechanical responses can then be estimated.

The most widely used method to model the biomechanical responses of TBI is through a finite element (FE) model of the human head (Yang et al. 2006) (illustrated in Fig. 1). This technique discretizes the spatial domain of...
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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biomedical Engineering, Department of Mechanical EngineeringWorcester Polytechnic InstituteWorcesterUSA

Section editors and affiliations

  • William W. Lytton
    • 1
  • Adam John Hunter Newton
    • 2
  1. 1.Downstate Medical CenterState University of New YorkBrooklynUSA
  2. 2.Department of NeuroscienceYale School of MedicineNew HavenUSA