Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Large-Scale Models of the Olfactory Bulb

  • Francesco CavarrettaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-7320-6_100664-1

Synonyms

Definition

The olfactory bulb is a small and self-contained neural system of the forebrain that is pivotally involved in producing the sense of the smell. Large-scale models of the olfactory bulb reconstruct extensive portion of it, including the main neuron populations, such as mitral, tufted, and granule cells, along with their connectivity. They are constituted by four components: (i) a model of odor inputs, (ii) cell models reproducing the salient properties of the main neuron types, (iii) the organization in glomeruli, and (iv) models of the feedforward and/or feedback inhibition mediated via glomerular and granule cell layers, respectively. Therefore, large-scale models of the olfactory bulb realize powerful frameworks to simulate the...

This is a preview of subscription content, log in to check access.

References

  1. Abraham NM, Spors H, Carleton A, Margrie TW, Kuner T, Schaefer AT (2004) Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice. Neuron 44:865–876PubMedGoogle Scholar
  2. Aungst JL, Heyward PM, Puche AC, Karnup SV, Hayar A, Szabo G, Shipley MT (2003) Centre-surround inhibition among olfactory bulb glomeruli. Nature 426:623–629CrossRefGoogle Scholar
  3. Breton-Provencher V, Bakhshetyan K, Hardy D, Bammann RR, Cavarretta F, Snapyan M, Côté D, Migliore M, Saghatelyan A (2016) Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb. Nat Commun 7:12659CrossRefGoogle Scholar
  4. Burton SD, Urban NN (2014) Greater excitability and firing irregularity of tufted cells underlies distinct afferent-evoked activity of olfactory bulb mitral and tufted cells. J Physiol 592:2097–2118CrossRefGoogle Scholar
  5. Burton SD, Urban NN (2015) Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb. J Neurosci 35(42):14103–22CrossRefGoogle Scholar
  6. Carey RM, Verhagen JV, Wesson DW, Pírez N, Wachowiak M (2009) Temporal structure of receptor neuron input to the olfactory bulb imaged in behaving rats. J Neurophysiol 10:1073–1088CrossRefGoogle Scholar
  7. Cavarretta F, Marasco A, Hines ML, Shepherd GM, Migliore M (2016) Glomerular and mitral-granule cell microcircuits coordinate temporal and spatial information processing in the olfactory bulb. Front Comput Neurosci 10:67CrossRefGoogle Scholar
  8. Cavarretta F, Burton SD, Igarashi KM, Shepherd GM, Hines ML, Migliore M (2018) Parallel odor processing by mitral and middle tufted cells in the olfactory bulb. Sci Rep 8:7625CrossRefGoogle Scholar
  9. Cleland TA, Linster C (2012) On-center/inhibitory-surround decorrelation via Intraglomerular inhibition in the olfactory bulb glomerular layer. Front Integr Neurosci 6:5CrossRefGoogle Scholar
  10. Cleland TA, Sethupathy P (2006) Non-topographical contrast enhancement in the olfactory bulb. BMC Neurosci 7, 7CrossRefGoogle Scholar
  11. Cruz G, Lowe G (2013) Neural coding of binary mixtures in a structurally related odorant pair. Sci Rep 3:1220CrossRefGoogle Scholar
  12. Geramita MA, Burton SD, Urban NN (2016) Distinct lateral inhibitory circuits drive parallel processing of sensory information in the mammalian olfactory bulb. Elife 5, pii: e16039Google Scholar
  13. Gilra A, Bhalla US (2015) Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding. PLoS One 10:e0098045CrossRefGoogle Scholar
  14. Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179–1209CrossRefGoogle Scholar
  15. Hines ML, Markram H, Schürmann F (2008) Fully implicit parallel simulation of single neurons. J Comput Neurosci 25:439–448CrossRefGoogle Scholar
  16. Hines ML, Kumar S, Schürmann F (2011) Comparison of neuronal spike exchange methods on a blue gene/P supercomputer. Front Comput Neurosci 5:49CrossRefGoogle Scholar
  17. Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500–544CrossRefGoogle Scholar
  18. Igarashi KM et al (2012) Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex. J Neurosci 32:7970–7985CrossRefGoogle Scholar
  19. Kim DH, Phillips ME, Chang AY, Patel HK, Nguyen KT, Willhite DC (2011) Lateral connectivity in the olfactory bulb is sparse and segregated. Front Neural Circuits 5:5Google Scholar
  20. Li G, Cleland TA (2013) A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb. J Neurosci 33:3037–3058CrossRefGoogle Scholar
  21. Migliore M, Cavarretta F, Hines ML, Shepherd GM (2013) Functional neurology of a brain system: a 3D olfactory bulb model to process natural odorants. Funct Neurol 28:241–243PubMedPubMedCentralGoogle Scholar
  22. Migliore M, Cavarretta F, Hines ML, Shepherd GM (2014) Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb. Front Comput Neurosci 8:50CrossRefGoogle Scholar
  23. Migliore M, Cavarretta F, Marasco A, Tulumello E, Hines ML, Shepherd GM (2015) Synaptic clusters function as odor operators in the olfactory bulb. Proc Natl Acad Sci U S A 112(27):8499–8504CrossRefGoogle Scholar
  24. Niessing J, Friedrich RW (2010) Olfactory pattern classification by discrete neuronal network states. Nature 465:47–52CrossRefGoogle Scholar
  25. Polese D, Martinelli E, Marco S, Di Natale C, Gutierrez-Galvez A (2014) Understanding odor information segregation in the olfactory bulb by means of mitral and tufted cells. PLoS One 9:e109716CrossRefGoogle Scholar
  26. Shepherd GM, Chen WR, Greer CA (2004) Olfactory bulb. In: Shepherd GM (ed) The synaptic Organization of the Brain, 5th edn. Oxford University Press, Oxford, pp 165–216CrossRefGoogle Scholar
  27. Shusterman R, Smear MC, Koulakov AA, Rinberg D (2011) Precise olfactory responses tile the sniff cycle. Nat Neurosci 14:1039–1044CrossRefGoogle Scholar
  28. Smear M, Shusterman R, O’Connor R, Bozza T, Rinberg D (2011) Perception of sniff phase in mouse olfaction. Nature 479:397–400CrossRefGoogle Scholar
  29. Vincis R, Gschwend O, Bhaukaurally K, Beroud J, Carleton A (2012) Dense representation of natural odorants in the mouse olfactory bulb. Nat Neurosci 15:537–539CrossRefGoogle Scholar
  30. Willhite DC, Nguyen KT, Masurkar AV, Greer CA, Shepherd GM, Chen WR (2006) Viral tracing identifies distributed columnar organization in the olfactory bulb. Proc Natl Acad Sci U S A 103:12592–12597CrossRefGoogle Scholar
  31. Yokoi M, Mori K, Nakanishi S (1995) Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb. Proc Natl Acad Sci U S A 92(8):3371–3375CrossRefGoogle Scholar
  32. Yu Y, McTavish TS, Hines ML, Shepherd GM, Valenti C, Migliore M (2013) Sparse distributed representation of odors in a large-scale olfactory bulb circuit. PLoS Comput Biol 9(3):e1003014CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Psychology, Department of Neurobiology and BehaviorCornell UniversityIthacaUSA

Section editors and affiliations

  • Michele Migliore
    • 1
    • 2
  1. 1.Department of NeurobiologyYale University School of MedicineNew HavenUSA
  2. 2.Institute of BiophysicsNational Research CouncilPalermoItaly