Encyclopedia of Computational Neuroscience

2015 Edition
| Editors: Dieter Jaeger, Ranu Jung

Biophysical Models of Olfactory Mitral and Granule Cells

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First Online:
DOI: https://doi.org/10.1007/978-1-4614-6675-8_606
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Definition

Biophysical models of olfactory mitral and granule cells are conductance-based compartmental models based on the morphological and electrophysiological properties of mitral and granule cells. Each cellular model incorporates a number of interconnected sections that represent physical cellular elements such as the soma, axon, dendrites, and/or specialized compartments such as spines. Each section, in turn, consists of one or more isopotential compartments, each of which contains passive and active ionic channels along with other mechanisms such as calcium buffering, typically modeled using the Hodgkin-Huxley formalism (Hodgkin and Huxley 1952). The parameters of these coupled equations are then adjusted to reproduce the salient membrane properties of mitral and granule cells. These biophysical models serve as an important tool to understand information processing within the olfactory bulb (OB) quantitatively.

Detailed Description

Morphological and Electrophysiological...

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of PsychologyCornell UniversityIthacaUSA