Living Reference Work Entry

Encyclopedia of Signaling Molecules

pp 1-13

Date: Latest Version

CD43

  • Alvaro Torres-HuertaAffiliated withInstituto de Biotecnología, Universidad Nacional Autónoma de México Email author 
  • , Estefania Aleman-NavarroAffiliated withInstituto de Biotecnología, Universidad Nacional Autónoma de México
  • , Maria Elena Bravo-AdameAffiliated withInstituto de Biotecnología, Universidad Nacional Autónoma de México
  • , Monserrat Alba Sandoval-HernandezAffiliated withInstituto de Biotecnología, Universidad Nacional Autónoma de México
  • , Oscar Arturo Migueles-LozanoAffiliated withInstituto de Biotecnología, Universidad Nacional Autónoma de México
  • , Yvonne RosensteinAffiliated withInstituto de Biotecnología, Universidad Nacional Autónoma de México

Synonyms

Galactoglycoprot​ein; Leukosialin; Sialophorin

Historical Background

CD43, also called sialophorin or leukosialin, was first identified as a defective molecule of leukocytes and platelets of patients affected with the Wiskott–Aldrich syndrome, yet the molecule responsible for this immunodeficiency turned out to be WASP. It was thought that expression of this heavily glycosylated, mucin-type membrane protein was restricted to hematopoietic cells. However, recent advances in the field evidence that CD43 is present in non-lymphoid tissues, particularly tumor cells. Here we reviewed the most important features about this molecule, highlighting the recent advances that have contributed to our understanding of the roles of CD43.

Gene Expression and Protein Structure

CD43 is a type I cell surface glycoprotein abundantly expressed on almost all hematopoietic cells, except for erythrocytes and resting B cells. Although initially considered an immune cell molecule, recent reports evidence a m ...

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