Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Plasma Membrane Calcium-Transporting ATPase

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DOI: https://doi.org/10.1007/978-1-4614-6438-9_133-1
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Synonyms

Plasma membrane Ca2+ ATPase; Plasma membrane Ca2+ pump; PMCA

Historical Background

The existence of a plasma membrane calcium-transporting ATPase (PMCA) that actively pumps Ca2+ ions out of the cell was first demonstrated in erythrocyte (red blood cell) membranes by Schatzmann (1966). Because of its generally low abundance and difficult biochemical properties, it took over a decade until the PMCA was first isolated in purified form. Crucial for the successful purification was the discovery that the PMCA binds with high affinity, and in a Ca2+-dependent manner, to the Ca2+ sensor protein calmodulin (Niggli et al. 1979). Subsequent work showed that at least one type of plasma membrane Ca2+ ATPase is found in all eukaryotic cells including those from fungi, animals, and plants (Axelsen and Palmgren 1998; Thever and Saier 2009). It is now well established that active Ca2+ expulsion by the PMCAs is an essential component of eukaryotic cellular Ca2+handling. Although, PMCAs were...

Keywords

Hair Cell Splice Variant Cerebellar Ataxia Export System Spinal Cord Pathology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyMayo Clinic College of Medicine and ScienceRochesterUSA
  2. 2.Department of BiomedicineUniversity of BaselBaselSwitzerland