Peroxisome Proliferator-Activated Receptor Alpha (PPAR-Alpha)
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The first peroxisome proliferator-activated receptor or PPAR was discovered as hormone receptor that was activated by rodent hepatocarcinogens that induced peroxisome proliferation (Issemann and Green 1990). PPARs are now known as a group of transcription factors that are able to induce transcription of genes that contain PPAR responsive elements (PPREs). The PPAR family of transcription factors consist of PPARα, β of δ (or nuclear receptor subfamily 1, group C, member 2 (NR1C2)), and γ (or nuclear receptor subfamily 1, group C, member 3 NR1C3). Here the focus is on PPARα that, in humans, is mainly expressed in tissue with high fatty acid oxidation like liver, muscle, heart, and kidney though also many other tissues do show expression of this family member. PPARα is thought to be a master regulator of lipid metabolism. It does so by...
KeywordsNonalcoholic Fatty Liver Disease Nuclear Receptor Subfamily Induce Peroxisome Proliferation PPAR Responsive Element Liver Tumor Development
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- Agarwal S, Yadav A, Chaturvedi RK. Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders. Biochem Biophys Res Commun. 2016. doi:10.1016/j.bbrc.2016.08.043.Google Scholar
- Bilandzic A, Fitzpatrick T, Rosella L, Henry D. Risk of bias in systematic reviews of non-randomized studies of adverse cardiovascular effects of thiazolidinediones and cyclooxygenase-2 inhibitors: application of a new cochrane risk of bias tool. PLoS Med. 2016;13:e100e1987. doi:10.1371/journal.pmed.1001987.CrossRefGoogle Scholar
- Krey G, Braissant O, L’Horset F, Kalkhoven E, Perroud M, Parker MG, et al. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol. 1997;11:779–91. doi:10.1210/mend.11.6.0007.CrossRefPubMedGoogle Scholar
- Thomas M, Bayha C, Klein K, Muller S, Weiss TS, Schwab M, et al. The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARalpha-tr, autonomously regulates proliferative and pro-inflammatory genes. BMC Cancer. 2015;15:488. doi:10.1186/s12885-015-1500-x.CrossRefPubMedPubMedCentralGoogle Scholar
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