Encyclopedia of Autism Spectrum Disorders

Living Edition
| Editors: Fred R. Volkmar


  • Lawrence D. ScahillEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6435-8_1274-3



Trazodone is an older antidepressant medication that has a mixed mechanism of action affecting multiple neurotransmitter systems. It is often used in adults as an adjunctive treatment for depression, particularly to aid with sleep. It has not been evaluated in children or adults with autism. The use of trazodone is avoided in males due to multiple reports of priapism. Priapism is an acute problem characterized by prolonged and painful erection.


References and Readings

  1. Gedye, A. (1991). Trazodone reduced aggressive and self-injurious movements in a mentally handicapped male patient with autism [letter]. Journal of Clinical Psychopharmacology, 11(4), 275–276.CrossRefGoogle Scholar
  2. Kem, D. L., Posey, D. J., & McDougle, C. J. (2002). Priapism associated with trazodone in an adolescent with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 41(7), 758.CrossRefGoogle Scholar
  3. Martin, A. M., Scahill, L., & Kratochvil, C. J. Pediatric psychopharmacology (pp. 263–274). New York: Oxford University Press.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Marcus Autism CenterChildren’s Healthcare of AtlantaAtlantaUSA
  2. 2.Department of PediatricsEmory UniversityAtlantaUSA