Pain in Autism Spectrum Disorders
Pain refers to “an unpleasant sensory and emotional experience associated with actual or potential tissue damage.” It is important therefore to understand that pain is more than a simple “ouch” and refers to the emotional, cognitive, and social aspects associated with potentially noxious physical sensations. Therefore, the current entry will focus on responses to tactile, thermal, and chemical stimuli which have the potential to result in unpleasant sensations. This entry will not consider distressing responses to emotional or other sensory experiences; for a review of these, see the entry “Sensory Processing”.
To understand both the experience of pain, the expression of pain, and the relationship of these to ASD, it is also important to consider the process by which pain is perceived and then communicated. When considering painful events that start in the periphery (e.g., pain resulting from an injury/tissue damage), it is often possible to see the noxious input,...
References and Reading
- Bandstra, N. F., Johnson, S. A., Filliter, J. H., & Chambers, C. T. (2012). Self-reported and parent-reported pain for common painful events in high-functioning children and adolescents with autism spectrum disorder. The Clinical Journal of Pain, 28(8), 715–721. https://doi.org/10.1097/AJP.0b013e318243ecf6.CrossRefGoogle Scholar
- Duerden, E. G., Card, D., Roberts, S. W., Mak-Fan, K. M., Chakravarty, M. M., Lerch, J. P., & Taylor, M. J. (2014). Self-injurious behaviours are associated with alterations in the somatosensory system in children with autism spectrum disorder. Brain Structure and Function, 219(4), 1251–1261.CrossRefGoogle Scholar
- Failla, M. D., Schwartz, K. L., Chaganti, S., Cutting, L. E., Landman, B. A., & Cascio, C. J. (2019). Characterizing co-occurring conditions by age at diagnosis in autism spectrum disorders. medRxiv:19002527.Google Scholar
- Gillberg, C., Terenius, L., & Lönnerholm, G. (1985). Endorphin activity in childhood psychosis: Spinal fluid levels in 24 cases. Archives of General Psychiatry, 42(8), 780–783. https://doi.org/10.1001/archpsyc.1985.01790310042005.CrossRefPubMedGoogle Scholar
- Krach, S., Kamp-Becker, I., Einhäuser, W., Sommer, J., Frässle, S., Jansen, A., Rademacher, L., Müller-Pinzler, L., Gazzola, V., & Paulus, F. M. (2015). Evidence from pupillometry and fMRI indicates reduced neural response during vicarious social pain but not physical pain in autism. Human Brain Mapping, 36, 4730–4744.CrossRefGoogle Scholar
- Lipsker, C. W., Bölte, S., Hirvikoski, T., Lekander, M., Holmström, L., & Wicksell, R. K. (2018). Prevalence of autism traits and attention-deficit hyperactivity disorder symptoms in a clinical sample of children and adolescents with chronic pain. Journal of Pain Research, 11, 2827.CrossRefGoogle Scholar
- Vaughan, S., McGlone, F., Poole, H., & Moore, D. J. (In press). A quantitative sensory testing approach to pain in autism spectrum disorders. Journal of Autism and Developmental Disorders.Google Scholar
- Williams, Z. J., Failla, M. D., Davis, S. L., Heflin, B. H., Okitondo, C. D., Moore, D. J., & Cascio, C. J. (2019). Thermal perceptual thresholds are typical in autism spectrum disorder but strongly related to intra-individual response variability. Scientific Reports, 9(1), 1–14.CrossRefGoogle Scholar
- Wing, L. (1976). Diagnosis, clinical description and prognosis. In L. Wing (Ed.), Early childhood autism (2nd ed.). Oxford: Pergamon Press.Google Scholar
- Wöhr, M., Orduz, D., Gregory, P., Moreno, H., Khan, U., Vörckel, K. J., Wolfer, D. P., Welzl, H., Gall, D., Schiffmann, S. N., & Schwaller, B. (2015). Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities. Translational Psychiatry, 5, e525.CrossRefGoogle Scholar