Encyclopedia of Autism Spectrum Disorders

Living Edition
| Editors: Fred R. Volkmar

Zyprexa

  • Jonathan KopelEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6435-8_102100-1

Synonyms

Definition

Despite advancements in cognitive-behavior therapies, no single pharmacological therapy has successfully treated the disruptive-compulsive behaviors of Autism Spectrum Disorders (ASD), which include hand-flapping, tantrums, and self-injurious behaviors (Fido and Al-Saad 2008). Among the pharmacological agents examined to reduce disruptive-compulsive behaviors, atypical antipsychotics, including olanzapine, showed the most promise (Fido and Al-Saad 2008; Malek-Ahmadi and Simonds 1998; Malone et al. 2001). Specifically, ASD children prescribed olanzapine showed significant reductions in irritability, hyperactivity, and lethargy (Fido and Al-Saad 2008; Malek-Ahmadi and Simonds 1998; Malone et al. 2001). Unlike typical antipsychotic medications, atypical antipsychotic medications block postsynaptic dopamine and serotonin receptors and have a lower risk of extrapyramidal symptoms, such as dyskinesias, among children and adolescents (Malone et al. 2001)....

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References and Reading

  1. Chiang, C.-l., Lin, Y.-H., & Hsieh, M. H. (2013). Olanzapine-induced hyponatremia in a patient with autism. Journal of Child and Adolescent Psychopharmacology, 23(10), 699–700.  https://doi.org/10.1089/cap.2013.0055.CrossRefPubMedGoogle Scholar
  2. Fido, A., & Al-Saad, S. (2008). Olanzapine in the treatment of behavioral problems associated with autism: An open-label trial in Kuwait. Medical Principles and Practice, 17(5), 415–418.  https://doi.org/10.1159/000141508.CrossRefPubMedGoogle Scholar
  3. Hergüner, S. (2010). Excessive masturbation associated with olanzapine in a pediatric case. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(7), 1349–1350.  https://doi.org/10.1016/j.pnpbp.2010.06.017.CrossRefPubMedGoogle Scholar
  4. Malek-Ahmadi, P., & Simonds, J. F. (1998). Olanzapine for autistic disorder with hyperactivity. Journal of the American Academy of Child & Adolescent Psychiatry, 37(9), 902–903.  https://doi.org/10.1097/00004583-199809000-00006.CrossRefGoogle Scholar
  5. Malone, R. P., Cater, J., Sheikh, R. M., Choudhury, M. S., & Delaney, M. A. (2001). Olanzapine versus haloperidol in children with autistic disorder: An open pilot study. Journal of the American Academy of Child & Adolescent Psychiatry, 40(8), 887–894.  https://doi.org/10.1097/00004583-200108000-00009.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Texas Tech University Health Sciences Center (TTUHSC)LubbockUSA