Encyclopedia of Autism Spectrum Disorders

Living Edition
| Editors: Fred R. Volkmar

Neurontin (Gabapentine)

  • Jonathan KopelEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6435-8_102091-1

Synonyms

Definition

Among Autism Spectrum Disorder (ASD) patients, insomnia and disruptive-compulsive behaviors remain difficult to manage from limited efficacy or adverse side effects with current pharmacological therapies (Blackmer and Feinstein 2016; Brown and Malow 2016; Guglielmo et al. 2013; Kotagal 2012). In recent years, antiepileptic drugs, specifically gabapentine, have become increasingly utilized for impulsive and aggressive behavior among neurodevelopmental disorders (Guglielmo et al. 2013). Gabapentin is an amino acid derivative used to treat anxiety disorders, alcohol dependence, insomnia, obsessive-compulsive disorder, and somatoform disorder (Guglielmo et al. 2013). Current research suggests gabapentin’s acts through α2-δ subunits of voltage-gated calcium channels, which modulate synaptic homeostasis within the nervous system (Guglielmo et al. 2013; Wang et al. 2016). Although effective, large-scale trials of gabapentine are needed to determine its efficacy...

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References and Reading

  1. Blackmer, A. B., & Feinstein, J. A. (2016). Management of sleep disorders in children with neurodevelopmental disorders: A review. Review of Therapeutics, 36(1), 84–98.Google Scholar
  2. Brown, K. M., & Malow, B. A. (2016). Pediatric Insomnia. Chest, 149(5), 1332–1339.  https://doi.org/10.1378/chest.15-0605.CrossRefPubMedGoogle Scholar
  3. Guglielmo, R., Ioime, L., Grandinetti, P., & Janiri, L. (2013). Managing disruptive and compulsive behaviors in adult with autistic disorder with gabapentin. Journal of Clinical Psychopharmacology, 33(2), 273–274.  https://doi.org/10.1097/jcp.0b013e318285680c.CrossRefPubMedGoogle Scholar
  4. Kotagal, S. (2012). Treatment of Dyssomnias and parasomnias in childhood. Current Treatment Options in Neurology, 14(6), 630–649.  https://doi.org/10.1007/s11940-012-0199-0.CrossRefPubMedGoogle Scholar
  5. Wang, T., Jones, R. T., Whippen, J. M., & Davi, G. W. (2016). α2δ-3 is required for rapid trans-synaptic homeostatic signaling. Cell Reports, 16(11), 2875–2888.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Texas Tech University Health Sciences Center (TTUHSC)LubbockUSA