A benzodiazepine medication used to relieve anxiety. Lorazepam is also used to treat irritable bowel syndrome, epilepsy, insomnia, nausea/vomiting from cancer treatment, and to control agitation caused by alcohol withdrawal. Additionally, it is used for surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. Lorazepam works by slowing activity in the brain to allow for relaxation. It acts as a sedative, hypnotic, anticonvulsant, and has muscle relaxant properties. Lorazepam primarily works by modifying the amount and action of gamma-aminobutyric acid (GABA), specifically enhancing the effects of the GABA neurotransmitter at the GABA receptors by increasing the frequency of opening of the chloride ion channels of the GABA receptors.
Lorazepam was developed by D.J. Richards, the President of Research of Wyeth Pharmaceuticals, in 1977. This benzodiazepine comes as a tablet or concentrate to take by...
References and Reading
- Pomara, N., Lee, S. H., Bruno, D., Silber, T., Greenblatt, D. J., Petkova, E., & Sidtis, J. J. (2015). Adverse performance effects of acute lorazepam administration in elderly long-term users: Pharmacokinetic and clinical predictors. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 56, 129–135.CrossRefGoogle Scholar