Encyclopedia of Autism Spectrum Disorders

Living Edition
| Editors: Fred R. Volkmar

Lamitctal (lamotrigine)

  • Tanuja GandhiEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6435-8_102081-1


Mechanisms of Action

Lamotrigine is an anticonvulsant. It works by inhibiting voltage-activated sodium channels, antagonizes N-type calcium channels, and also has antiglutamatergic action. The antiglutaminergic effect is thought to be through inhibition of sodium, calcium, and potassium channels leading to decreased release of the excitatory amino acid glutamate. While there are studies to show potential favorable effects on cognition and mood stabilization, there is currently insufficient evidence to support the use of lamotrigine in Autism Spectrum Disorder

Specific Compounds and Properties

Lamotrigine is an antiepileptic drug of the phenyltriazine class.

References and Reading


  1. Schatzberg, A. F., & Nemeroff, C. B. (Eds.). (2017). The American Psychiatric Association Publishing textbook of psychopharmacology. American Psychiatric Publishing.Google Scholar
  2. McVoy, M., & Findling, R. L. (Eds.). (2017). Clinical manual of child and adolescent psychopharmacology. American Psychiatric Publishing.Google Scholar

Articles in Journal

  1. Belsito, K. M., Law, P. A., Kirk, K. S., Landa, R. J., & Zimmerman, A. W. (2001). Lamotrigine therapy for autistic disorder: a randomized, double-blind, placebo-controlled trial. Journal of Autism and Developmental Disorders, 31(2), 175–181.CrossRefGoogle Scholar
  2. Kumar, B., Prakash, A., Sewal, R. K., Medhi, B., & Modi, M. (2012). Drug therapy in autism: a present and future perspective. Pharmacological Reports, 64(6), 1291–1304.CrossRefGoogle Scholar
  3. Bromley, R. L., Mawer, G. E., Briggs, M., Cheyne, C., Clayton-Smith, J., García-Fiñana, M., … & Liverpool and Manchester Neurodevelopment Group. (2013). The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. Journal of Neurology, Neurosurgery, and Psychiatry.  https://doi.org/10.1136/jnnp-2012-304270.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Child Study Centre, Yale School of MedicineNew HavenUSA