Precancerous Lesions of the Cervix

  • Thomas C. WrightEmail author
  • Brigitte M. Ronnett
  • Robert J. Kurman
Living reference work entry


This chapter covers the epidemiology, pathogenesis, current nomenclature, and histological appearances of precancerous lesions of the cervix. For over 20 years, it has been evident that specific types of human papillomavirus (HPV) cause almost all squamous cell carcinomas of the cervix as well as the vast majority of adenocarcinomas of the cervix. However, much remains to be learned regarding the precise molecular pathways by which these DNA tumor viruses produce tumors and why only a small minority of HPV- infected individuals develop disease. The chapter discusses the current terminology used to refer to precancerous lesions including both squamous and glandular lesions. The chapter then provides an in- depth description of the histological features of both squamous intraepithelial lesions and glandular neoplasia. This includes both their differential diagnoses and the use of adjunctive histological methods including p16.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Thomas C. Wright
    • 1
    Email author
  • Brigitte M. Ronnett
    • 2
  • Robert J. Kurman
    • 3
  1. 1.Department of Pathology and Cell BiologyColumbia UniversityNew YorkUSA
  2. 2.Department of Pathology, Division of Gynecologic PathologyJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Departments of Gynecology, Obstetrics, Pathology and Oncology, Division of Gynecologic PathologyJohns Hopkins University School of MedicineBaltimoreUSA

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