Psychostimulants and Addiction

  • Luigi Pulvirenti
  • Michel Le Moal
  • George F. Koob
Reference work entry

Abstract

Psychomotor stimulants belong to two major classes: direct and indirect sympathomimetics (such as cocaine and amphetamine) and nonsympathomimetics. This chapter will focus on indirect sympathomimetics. These compounds include drugs such as cocaine and amphetamines, which share a common molecular structure – a benzene ring with an ethylamine side chain.

Keywords

Nucleus Accumbens Psychomotor Stimulant Extended Amygdala Acute Withdrawal Reward Threshold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgment

We are grateful to Mike Arends for editorial assistance.

Further Reading

  1. Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282:298–300PubMedCrossRefGoogle Scholar
  2. Aston-Jones G, Harris GC (2004) Brain substrates for increased drug seeking during protracted withdrawal. Neuropharmacology 47(Suppl 1):167–179PubMedCrossRefGoogle Scholar
  3. Childress AR, Mozley PD, McElgin W, Fitzgerald J, Reivich M, O’Brien CP (1999) Limbic activation during cue-induced cocaine craving. Am J Psychiatry 156:11–18PubMedGoogle Scholar
  4. Everitt BJ, Wolf ME (2002) Psychomotor stimulant addiction: a neural systems perspective. J Neurosci 22:3312–3320PubMedGoogle Scholar
  5. Heimer L, Alheid G (1991) Piecing together the puzzle of basal forebrain anatomy. In: Napier TC, Kalivas PW, Hanin I (eds) The basal forebrain: anatomy to function, vol 295, Advances in experimental medicine and biology. Plenum, New York, pp 1–42CrossRefGoogle Scholar
  6. Hyman SE, Malenka RC (2001) Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci 2:695–703PubMedCrossRefGoogle Scholar
  7. Kalivas PW, McFarland K (2003) Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology 168:44–56PubMedCrossRefGoogle Scholar
  8. Koob GF, Volkow ND (2010) Neurocircuitry of addiction. Neuropsychopharmacology 35(1):217–238PubMedCrossRefGoogle Scholar
  9. Nader MA, Daunais JB, Moore T, Nader SH, Moore RJ, Smith HR, Friedman DP, Porrino LJ (2002) Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology 27:35–46PubMedCrossRefGoogle Scholar
  10. Nestler EJ (2004) Historical review: molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol Sci 25:210–218PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Luigi Pulvirenti
    • 1
  • Michel Le Moal
    • 2
  • George F. Koob
    • 3
  1. 1.Neuroscience School of Advanced Studies San Quirico d’OrciaSienaItaly
  2. 2.3INSERM, U862, Neurocentre Magendie Neurogenesis and Physiopathology GroupBordeauxFrance
  3. 3.Committee on the Neurobiology of Addictive DisordersThe Scripps Research InstituteLa JollaUSA

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