Proteomic Basis of Cisplatin Resistance
Cisplatin along with other platinum-based drugs including oxaliplatin, carboplatin are some of the most widely used chemotherapeutic agents. Unfortunately, drug resistance remains a major problem for the successful chemotherapeutic treatment of cancer. Current evidence suggests that resistance toward platinum chemotherapeutics is a multifactorial problem due to changes in the expression levels and activities of a wide number of proteins.
Cisplatin Resistance and Changes to the Proteome
This laboratory is grateful for support from the National Institutes of Health through grant numbers: 5R01RR023334, 1R01GM097112, 5R01GM086688, 7S10RR025107, and 1R01HL110879.