Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Aquaporins and Transport of Metalloids

  • François Chaumont
  • Gerd Patrick Bienert
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_469



Aquaporins or major intrinsic proteins (MIPs) are channels facilitating the passive diffusion of small uncharged solutes across biological membranes. In addition to water, several aquaporin isoforms were shown to transport gases (NH3 and CO2) or other uncharged solutes including metalloid compounds (arsenite, boric acid, silicic acid, selenite, and antimonite).

Aquaporin Discovery and Phylogeny

Aquaporins are membrane proteins belonging to the ancient major intrinsic protein (MIP) family whose members are found in all kingdoms of life. Although the term aquaporin was initially restricted to MIPs transporting water molecules, it is now used to describe all MIPs.

The first demonstration of the water channel activity of a MIP protein was published in 1992 when Peter Agre and coworkers heterologously expressed in Xenopus oocytes a 28-kDa protein (CHIP28) from human erythrocyte membrane...

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Institut des Sciences de la VieUniversite catholique de LouvainLouvain-la-NeuveBelgium