Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Porous Silicon for Drug Delivery

  • Hélder A. SantosEmail author
  • Jarno Salonen
  • Luis M. Bimbo
Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_447



 Porous silicon (PSi) refers to a material containing interconnected networks of empty holes (pores) in a Si structure, rendering the material with a large surface-to-volume ratio properties. PSi materials are classified according to pore diameter, that can vary from a few nanometers to a few micrometers depending on the fabrication parameters. Most commonly, the PSi structure is referred as mesoporous (pores with diameters between 2 and 50 nm). Sometimes the word “nanoporous” is used instead of mesopores to emphasize the nanometric dimension of the pores. The volumetric fraction of empty space (voids) in the structure of the material is called porosity. The internal surface area of PSi per volume unit can be as large as 500 m2/cm3 and can act as reservoirs for storing therapeutic compounds for drug delivery applications.

Fabrication Procedures and Role in Drug...

This is a preview of subscription content, log in to check access.


  1. Bimbo LM, Sarparanta M, Santos HA et al (2010) Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats. ACS Nano 4:3023–3032PubMedGoogle Scholar
  2. Bimbo LM, Mäkilä E, Raula J et al (2011) Functional hydrophobin-coating of thermally hydrocarbonized porous silicon microparticles. Biomaterials 32:9089–9099PubMedGoogle Scholar
  3. Canham LT (ed) (1997) Properties of porous silicon. Short Run Press, LondonGoogle Scholar
  4. Godin B, Tasciotti E, Liu X et al (2011) Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics. Acc Chem Res 44:979–989PubMedGoogle Scholar
  5. Heinrich JL, Curtis CL, Credo GM, Kavanagh KL, Sailor MJ (1992) Luminescent colloidal silicon suspensions from porous silicon. Science 255:66–68PubMedGoogle Scholar
  6. Kilpeläinen M et al (2009) In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles. J Control Release 37:166–170Google Scholar
  7. Kovalainen M, Mönkäre J, Mäkilä E et al (2011) Mesoporous silicon (PSi) for sustained peptide delivery: effect of PSi microparticle surface chemistry on peptide YY3-36 release. Pharm Res 29:837–846PubMedGoogle Scholar
  8. Lehto V-P, Salonen J, Santos HA, Riikonen J (2012) In: Douroumis D, Fahr A (eds) Nanostructured silicon based materials as a drug delivery system for insoluble drugs. Wiley-Blackwell, WeinheimGoogle Scholar
  9. Sailor MJ (ed) (2011) Porous silicon in practice: preparation, characterization and applications. Wiley-VCH, WeinheimGoogle Scholar
  10. Salonen J, Kaukonen AM, Hirvonen J, Lehto V-P (2008) Mesoporous silicon in drug delivery applications. J Pharm Sci 97:632–653PubMedGoogle Scholar
  11. Santos HA, Riikonen J, Salonen J et al (2010) In vitro cytotoxicity of porous silicon microparticles: effect of the particle concentration, surface chemistry and size. Acta Biomater 6:2721–2731PubMedGoogle Scholar
  12. Santos HA, Bimbo LM, Lehto V-P et al (2011) Multifunctional porous silicon for therapeutic drug delivery and imaging. Curr Drug Discov Techol 8:228–249Google Scholar
  13. Sarparanta M, Mäkilä E, Heikkilä T et al (2011) 18F-labeled modified porous silicon particles for investigation of drug delivery carrier distribution in vivo with positron emission tomography. Mol Pharmaceutics 8:1799–1806Google Scholar
  14. Sarparanta MP, Bimbo LM, Mäkilä EM et al (2012) The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems. Biomaterials 33:3353–3362PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hélder A. Santos
    • 1
    Email author
  • Jarno Salonen
    • 2
  • Luis M. Bimbo
    • 1
  1. 1.Division of Pharmaceutical TechnologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Laboratory of Industrial Physics, Department of PhysicsUniversity of TurkuTurkuFinland