Calcium-Binding Protein Site Types
Calcium: A soft gray alkaline earth metal. Ionic calcium (Ca2+) is essential for numerous cellular functions, as well as biomineralization.
Calcium-binding protein: Any protein or enzyme that requires the binding of a calcium ion to fulfill either a functional or structural role.
Binding site: Region in the protein where metal ions will bind as a result of electrostatic interactions with ligands of opposite charge.
Ligand: Ion, atom, or molecule that binds to a metal ion to form a coordination complex.
Tertiary structure: Three-dimensional shape of a protein, enzyme, or molecule.
Diverse Roles of Calcium-Binding Proteins
In the intracellular environment, calcium functions as a second messenger to facilitate a wide variety of functions related to muscle contraction, neurotransmitter release, and enzyme activation. Additionally, calcium and calcium-binding proteins (CaBPs) are involved in almost every aspect of the...