Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Zinc Sensors in Bacteria

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_207



Zinc sensors detect when critical thresholds in the amounts of zinc within cells have been surpassed. The sensors detect either (1) zinc excess to trigger removal, use, or storage of surplus atoms or (2) zinc deficiency to trigger acquisition of more atoms or to reduce demand.

Overview of Zinc Sensors in Bacteria

Bacteria possess multiple types (families) of DNA-binding, zinc-sensing regulators of gene transcription (Ma et al. 2009). Other family members detect other metals. More than one type of zinc sensor is commonly present in a cell. Membrane-associated two-component sensors which transduce the metal signal to a separate DNA-binding transcriptional regulator are known for some metals but are either absent or yet to be described for zinc.

Bacterial zinc sensors bind to the operator-promoter regions of genes encoding zinc export proteins...

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  1. Changela A, Chen K, Holschen J, Outten CE, O’Halloran TV, Mondragon A (2003) Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. Science 301:1383–1387PubMedCrossRefGoogle Scholar
  2. Lee J-W, Helmann JD (2007) Functional specialisation within the Fur Family of metalloregulators. Biometals 20:485–499PubMedCrossRefGoogle Scholar
  3. Lucarelli D, Vasil ML, Meyer-Klaucke W, Pohl E (2008) The metal-dependent regulators FurA and FurB from Mycobacterium tuberculosis. Int J Mol Sci 9:1548–1560PubMedCrossRefGoogle Scholar
  4. Ma Z, Jacobsen FE, Giedroc DP (2009) Coordination chemistry of bacterial metal transport and sensing. Chem Rev 109:4644–4681PubMedCrossRefGoogle Scholar
  5. Osman D, Cavet JS (2010) Bacterial metal-sensing proteins exemplified by ArsR-SmtB family repressors. Nat Prod Rep 27:668–680PubMedCrossRefGoogle Scholar
  6. Outten CE, O’Halloran TV (2001) Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis Science 292:2488–2492Google Scholar
  7. Pruteanu M, Baker TA (2009) Proteolysis in the SOS response and metal homeostasis in Escherichia coli. Res Microbiol 160:677–683PubMedCrossRefGoogle Scholar
  8. Reyes-Caballero H, Guerra AJ, Jacobsen FE, Kazmeirczak KM, Cowart D, Koppolu UMK, Scott RA, Winkler ME, Giedroc DP (2010) The metalloregulatory zinc site in Streptococcus pneumoniae AdcR, a zinc-activated MarR family repressor. J Mol Biol 403:197–216PubMedCrossRefGoogle Scholar
  9. Waldron KJ, Rutherford JC, Ford D, Robinson NJ (2009) Metalloproteins and metal sensing. Nature 460:823–830PubMedCrossRefGoogle Scholar
  10. Waldron KJ, Robinson NJ (2009) How do bacterial cells ensure that metalloproteins get the correct metals? Nat Rev Microbiol 7:25–35PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Biophysical Sciences Institute, Department of Chemistry, School of Biological and Biomedical SciencesDurham UniversityDurhamUK