Encyclopedia of Metalloproteins

2013 Edition
| Editors: Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov

Zinc Sensors in Bacteria

Reference work entry
DOI: https://doi.org/10.1007/978-1-4614-1533-6_207

Synonyms

Definition

Zinc sensors detect when critical thresholds in the amounts of zinc within cells have been surpassed. The sensors detect either (1) zinc excess to trigger removal, use, or storage of surplus atoms or (2) zinc deficiency to trigger acquisition of more atoms or to reduce demand.

Overview of Zinc Sensors in Bacteria

Bacteria possess multiple types (families) of DNA-binding, zinc-sensing regulators of gene transcription (Ma et al. 2009). Other family members detect other metals. More than one type of zinc sensor is commonly present in a cell. Membrane-associated two-component sensors which transduce the metal signal to a separate DNA-binding transcriptional regulator are known for some metals but are either absent or yet to be described for zinc.

Bacterial zinc sensors bind to the operator-promoter regions of genes encoding zinc export proteins...

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References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Biophysical Sciences Institute, Department of Chemistry, School of Biological and Biomedical SciencesDurham UniversityDurhamUK