Febrifugine

Reference work entry

CAS Registry Number: 24159-07-7 Open image in new window

Taxonomy: Physicochemical and Pharmacological Properties of Alkaloids – Quinazoline and Quinazolone Alkaloids

Biological sources: Dichroa febrifuga

C₁₆H₁₉N₃O₃: 301.1426

Mp: 152–154°C (CHCl₃), 218°C (dec., di hydrochloride), 230°C (sulphate) [1]

[α]_D +21° (EtOH) [1]

Solubility: sol. EtOH, Me₂CO, CHCl₃, H₂O; spar. sol. C₆H₆, Et₂O [1]

UV: 225, 266, 275, 302, 312(4.40, 3.84, 3.82, 3.68, 3.45) [2]

IR: [1]

Pharm./Biol.: LD₅₀ 2.7 mg/kg (mice) [3]. Antimalarial and antitumoral activity [1]

This is a preview of subscription content, to check access.

References

1.
E.S. Zabolotnaya, L.N. Safronich, in: Tr. VILR, Lekarstvennye rastenya 15, 356 (1969)Google Scholar
2.
A.W. Sangster, R.L. Stuart, Chem. Rev. 65, 69 (1965)CrossRefGoogle Scholar
3.
J.B. Koepfli, J.F. Mead, J.A. Brockman, J. Amer. Chem. Soc. 71, 1048 (1949)CrossRefGoogle Scholar