Definition
A series of characteristic immunological parameters used to measure vaccine-induced immune responses, e.g.,
- 1.
Innate immune responses
- (a)
Dendritic cell activation (Pulendran 2004)
- (b)
Inflammatory response
- (c)
Complement activation
- (a)
- 2.
Adaptive immune responses
- (i)
Antibody and B cell immune responses (Subbarao and Robertson 2006)
Neutralizing Ab (Ochsenbauer and Kappes 2009)
Non-neutralizing Ab
Antibody-dependent cell cytotoxicity (ADCC)
- (ii)
T-cell immune responses (Seder et al. 2008)
Lysis (CTL)
Tetramer
Cytokines
- (iii)
Lymphocyte repertoire diversity
Immunoscope/CDR3 spectratyping
TCR/Ig rearrangement quantification
TCR/Ig deep sequencing
- (i)
See Lymphocyte Dynamics and Repertoires, Biological Methods.
The rapid progress in flow cytometry implies that an increasing number of parameters can be looked at simultaneously, which is highly relevant for a more comprehensive assessment of lymphocyte...
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References
Ochsenbauer C, Kappes JC (2009) New virologic reagents for neutralizing antibody assays. Curr Opin HIV AIDS 5:418–425
Pulendran B (2004) Modulating vaccine responses with dendritic cells and Toll-like receptors. Immunol Rev 199:227–250
Seder RA, Darrah PA, Roederer M (2008) T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 4:247–258
Subbarao B, Robertson DA (2006) Assays for B lymphocyte function Chap 3, unit 3.8. In John E. Colegan et al. (eds) Current Protocols in Immunology. Wiley Inter Science, Hoboken
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Bellier, B., Six, A., Thomas-Vaslin, V., Klatzmann, D. (2013). Immunomonitoring. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_716
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