Modeling Formalisms, Lymphocyte Dynamics and Repertoires
Modeling a biological system can be done by representation of the structure of the objects (organs, lymphocytes populations, cells, etc.) with the help of ontologies and their relationship and their behavior in time (participation to processes like division, death, selection, migration, etc.). This biological modeling can help to develop further computational modeling and mathematical modeling. Representation of concepts (structure) and processes (behavior) can be done using UML state and transition visual diagrams.
Top-Down Versus Bottom-Up Modeling Approaches
In the top-down approach, knowledge of the system is established by global data mining, integration, and statistical analysis, from which the individual patterns or mechanisms are deduced.
In the bottom-up approach, basic components and mechanisms are...
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