Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Modeling, Cell Division and Proliferation

  • Véronique Thomas-VaslinEmail author
  • Adrien Six
  • Bertrand Bellier
  • David Klatzmann
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_714



Upon division, one mother cell generates two daughter cells that can differ from the mother (gene rearrangement, differentiation, mutation, incorporation of a radioactive element or a dye, etc.). Estimation of cell division/proliferation and modeling depends on the method(s) used (  Lymphocyte Dynamics and Repertoires, Biological Methods) and also of biological features:
  • Method(s) are reviewed in (Hellerstein 1999; Asquith et al. 2002).

  • Cell death, recirculation to other lymphoid compartments, and heterogeneity of the assessed population are factors that can impact and complicate DNA labeling interpretation (Asquith et al. 2002).

  • Lymphocyte population expansion depends on (1) the presence and concentration of antigen in the local environment, (2) selection processes related to...

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  1. Asquith B, Debacq C et al (2002) Lymphocyte kinetics: the interpretation of labelling data. Trends Immunol 23(12):596–601CrossRefPubMedGoogle Scholar
  2. De Boer RJ, Ganusov VV et al (2006) Estimating lymphocyte division and death rates from CFSE data. Bull Math Biol 68(5):1011–1031CrossRefPubMedGoogle Scholar
  3. Hellerstein MK (1999) Measurement of T-cell kinetics: recent methodologic advances. Immunol Today 20(10):438–441CrossRefPubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Véronique Thomas-Vaslin
    • 1
    Email author
  • Adrien Six
    • 1
  • Bertrand Bellier
    • 1
  • David Klatzmann
    • 1
  1. 1.Immunology-Immunopathology-ImmunotherapyUPMC University Paris 06, UMR7211, CNRS, UMR7211, INSERM, U959ParisFrance