Lymphocyte Population Kinetics

Thomas-Vaslin, Véronique; Six, Adrien; Bellier, Bertrand; Klatzmann, David

doi:10.1007/978-1-4419-9863-7_713

Lymphocyte Population Kinetics

Véronique Thomas-Vaslin⁵,
Adrien Six⁵,
Bertrand Bellier⁵ &
…
David Klatzmann⁵

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Synonyms

Death rate; Depletion rate; Equilibrium; Half-life; Homeostasis; Input; Kinetics; Life span; Output; Persistence; Proliferation rate; Steady state

Definition

Lymphocyte population kinetics refers to the behavior of cells, how cells differentiate, mature or migrate with time, and how they fluctuate to external influences.

Lymphocyte kinetics and homeostasis of lymphoid compartments have been explored in various context for B (Freitas et al. 1986) or T lymphocytes (Thomas-Vaslin et al. 2008; Callard and Hodgkin 2007).

Lymphocyte population kinetics allows to follow growth and decay of cell populations as a function of time. Lymphocyte percentages and numbers can be followed overtime in a single individual (patient, mouse, etc), after transfer, cell depletion, treatments, etc.

Examples of typical observed data are provided in Figs. 1 and 2and the possible interpretations are given below. The kinetics of an identified lymphocyte population can be more complex than initially...

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References

Callard R, Hodgkin P (2007) Modeling T- and B-cell growth and differentiation. Immunol Rev 216:119–129
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Freitas AA, Rocha B et al (1986) Lymphocyte population kinetics in mice. Immunol Rev 91:5–37
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Thomas-Vaslin V, Altes HK et al (2008) Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis. J Immunol 180(4):2240–2250
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Authors and Affiliations

Immunology-Immunopathology-Immunotherapy, UPMC University Paris 06, UMR7211, CNRS, UMR7211, INSERM, U959, 75013, Paris, France
Dr. Véronique Thomas-Vaslin, Dr. Adrien Six, Bertrand Bellier & Dr. David Klatzmann

Authors

Dr. Véronique Thomas-Vaslin
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Dr. Adrien Six
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Bertrand Bellier
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Dr. David Klatzmann
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Corresponding author

Correspondence to Véronique Thomas-Vaslin .

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Editors and Affiliations

Biomedical Sciences Research Institute, University of Ulster, Coleraine, UK
Werner Dubitzky
Department of Computer Science, University of Rostock, Rostock, Germany
Olaf Wolkenhauer
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
Kwang-Hyun Cho
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA
Hiroki Yokota

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Thomas-Vaslin, V., Six, A., Bellier, B., Klatzmann, D. (2013). Lymphocyte Population Kinetics. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_713

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DOI: https://doi.org/10.1007/978-1-4419-9863-7_713
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-9862-0
Online ISBN: 978-1-4419-9863-7
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